Natural Killer Cells

Question 1

What type of cells can kills virus- infected cells, tumor cells, stressed cells, some bacteria without prior activation, and parasitic worms?

Answer 1

NK cells

Question 2

What type of cells act as a first line of defense against pathogens such as viruses?

Answer 2

NK cells

Question 3

What type of cells use different types of receptors to recognize their targets?

Answer 3

NK cells

Question 4

What type of cells recognize and attack target cells that express certain stress-associated molecules?

Answer 4

NK cells

Question 5

What type of cells are located in bone marrow, peripheral blood, spleen, and lymph nodes?

Answer 5

NK cells

Question 6

What type of cells are cytotoxic innate cells?

Answer 6

NK cells

Question 7

When a target cell fails to express MCH class 1 molecules, what type of cells lose their inhibitions about attacking such cells?

Answer 7

NK cells

Question 8

What type of cells may be activated by the expression of stress-related proteins on target cells?

Answer 8

NK cells

Question 9

What binds to MCH (target cell) which results in inhibition/activation?

Answer 9

Killer cell immunoglobulin (Ig)- like receptor - KIR

Question 10

KIR, Ly49 receptor, NKG2D receptor, and Fc receptor are examples of what type of cell receptors?

Answer 10

NK cell receptors

Question 11

What type of molecules do mice rely on for the recognition of their MHC ligands?

Answer 11

Ly49

Question 12

What type of cell recognizes MHC class 1 molecules and suppresses NK cytotoxicity?

Answer 12

Ly49

Question 13

What type of receptor is expressed on stressed, virus-infected, or tumor cells?

Answer 13

NKG2D

Question 14

What binds immunoglobulins and triggers target cell death by antibody-dependent cellular cytotoxicity?

Answer 14

CD16

Question 15

What types of cells may be replaced by KIR receptors?

Answer 15

Ly49

Question 16

What is a potent stimulant of both NK cells and macrophages?

Answer 16

IFN- y

Question 17

What is name for when a cell dies by target cell?

Answer 17

Apoptosis

Question 18

What type of cells are always “on call”?

Answer 18

NK cells

Question 19

What type of cells may develop “memory” to some antigens for several months?

Answer 19

NK cells

Question 20

What type of cells share properties with both NK and T cells?

Answer 20

NKT cells

Question 21

What type of cell serves as a bridge between innate and adaptive immunity?

Answer 21

NKT cells

Question 22

What do normal healthy cells express which inhibit NK cell activity?

Answer 22

MHC 1

Question 23

If cells express altered MHC 1, will inhibitory signals be activated?

Answer 23

No