Inflammation 2- Innate Immunity Flashcards
High counts of what in milk are indicative of acute mastitis?
Leukocytes
What are the 4 major signs of acute inflammation?
Pain, redness, heat, and swelling
What causes pain in acute inflammation?
Nerve damage
Vasoactive molecules that leads to increased blood flow causes what 2 signs of acute inflammation?
Redness and heat
Vasoactive molecules that lead to increased vascular permeability, and chemotactic molecules that lead to neutrophil emigration, causes which sign of acute inflammation?
Swelling
TNF-a, Interleukin 1 and 6, are examples of what?
Pro-inflammatory cytokines
What factor do macrophages, monocytes, T-cells, and mast cells produce?
Tumor necrosis factor
What type of factors activate cells, had toxic effects, enhances fibroblast growth, collagen synthesis, and bone resorption, and promotes inflammation 1?
Tumor necrosis factor
What promotes inflammation, kills cells, affects leukocytes, affects the brain, affects cell growth, affects blood flow, and affects metabolism?
Interleukin 1
What regulates the transition from early neutrophil dominated inflammatory process to later macrophage inflammatory process?
Interleukin 6
Chronic inflammation= high levels of what?
Macrophages
Acute inflammation = high levels of what?
Neutrophils
What can have some inhibition of TNF and IL 1?
IL 6
What has effect on T and B cells, hepatocytes, and the brain(fever)?
IL 6
How many different types of antibodies are there?
5
What is the most abundant antibody?
IGG
What are produced by sentinel cells?
Chemokines
How many classified families do chemokines have?
4
What coordinates the migration of cells and dictates the course of many inflammatory and immune responses?
Chemokines
What is the one additional inflammatory symptom?
Loss of function
What is an example of vasoactive amines?
Mast cells
What’s an example of vasoactive peptides?
C5a
What is an example of vasoactive lipids?
Sentinel cells
What are the leukocytes doing there?
Fighting against microorganisms- phagocytosis
How did they get there?
Leukocyte extravasation
How do leukocytes know where to go?
Chemokines
