Naloxone & Ondansetron

Question 1

Naloxone Trade Name:

Answer 1

Narcan®

Question 2

Naloxone classes:

Answer 2

Narcotic antagonist

Question 3

Naloxone Standard Supply:

Answer 3

Prefilled syringe

Question 4

Naloxone MOA:

Answer 4

-Acts as a competitive antagonist at opiate receptors in the CNS
-Reverses the effects of narcotic and synthetic analgesic drugs
*CNS depression
*Respiratory depression
*Respiratory arrest

Question 5

Naloxone indications:

Answer 5

-Narcotic and synthetic analgesic drug overdoses
*morphine, heroin, oxycodone, methadone, codeine, meperidine, fentanyl, hydrocodone, hydromorphone
-Unconsciousness of unknown etiology

Question 6

Naloxone Contraindication:

Answer 6

None in emergency setting

Question 7

Naloxone S/E:

Answer 7

-Withdrawal symptoms: Confusion, Hypotension, Tachycardia, Hypertension, Dysrhythmias, Diaphoresis, Nausea/vomiting

Question 8

Naloxone Routes:

Answer 8

-IV
-IM
-IO
-ET
-IN

Question 9

Naloxone Onset:

Answer 9

2-10 min

Question 10

Naloxone Adult dosages:

Answer 10

-2.0 mg; may repeat every 2 min
-ET: 4.0 mg diluted in 10 mL saline
-IN: 1.0 mg sprayed in each nostril w/ MAD; may repeat every 2 min

Question 11

Naloxone PEDS dosages:

Answer 11

-0.1 mg/kg (up to 2.0 mg per dosage); may repeat every 2 min
-ET: 2.0-4.0 mg diluted in 3-5 mL saline
-IN: 1.0 mg sprayed in each nostril w/ MAD; may repeat every 2 min

Question 12

Ondansetron Trade Name:

Answer 12

Zofran®

Question 13

Ondansetron Class:

Answer 13

Antiemetic

Question 14

Ondansetron Standard supplies:

Answer 14

-Orally disintegrating tablet (ODT)
-Vial

Question 15

Ondansetron MOA:

Answer 15

-Blocks serotonin 5-HT3 receptor sites in the CNS
-Inhibits nausea and vomiting

Question 16

Ondansetron Indication:

Answer 16

Nausea and vomiting

Question 17

Ondansetron Contraindication:

Answer 17

Hypersensitivity

Question 18

Ondansetron S/E:

Answer 18

-Headache
-Dizziness

Question 19

Ondansetron Routes:

Answer 19

-Oral
-IV
-IO

Question 20

Ondansetron Onset:

Answer 20

5-10 min

Question 21

Ondansetron Adult dosages:

Answer 21

-Oral: 8.0 mg
-IV/IO: 4.0-8.0 mg over 2-5 min

Question 22

Ondansetron PEDS dosages:

Answer 22

-4-14 years oral/IV/IO: 4.0 mg; max dosage 4.0 mg