mag sulfate & methylprednisolone

Question 1

Magnesium Sulfate Classes:

Answer 1

-Electrolyte
-Anti-inflammatory
-Tocolytic (labor suppressant)

Question 2

Magnesium Sulfate Supply & Route:

Answer 2

-Vial
-IV/IO/Infusion

Question 3

Magnesium Sulfate MOA:

Answer 3

-Decreases ventricular irritability
-Decreases release of acetylcholine that inhibits muscular excitability
-Causes uterine relaxation
-Relaxes bronchial smooth muscle resulting in bronchodilation

Question 4

Magnesium sulfate Indications:

Answer 4

-Seizures caused by toxicity of pregnancy (toxemia)
-Pregnancy induced hypertension (pre-eclampsia and eclampsia)
-Pre-term labor
-Torsades de pointes (polymorphic ventricular tachycardia)
-Ventricular fibrillation and pulseless ventricular tachycardia refractory to amiodarone or lidocaine
-Reactive airway conditions including bronchoconstriction and bronchospasm

Question 5

Magnesium Sulfate Contraindication:

Answer 5

Hemodynamically significant heart block

Question 6

Magnesium Sulfate S/E:

Answer 6

-CNS depression
-Drowsiness
-Hypotension
-Respiratory depression
-Dysrhythmias

Question 7

Magnesium Sulfate Onset:

Answer 7

Immediate

Question 8

Magnesium Sulfate Adult dosages:

Answer 8

-Torsades de pointe infusion: 1.0-2.0g in 50 to 100 mL over 5 minutes *may repeat 1-2g over 1 hour
-Preterm labor/pre-eclampsia infusion: 3.0-6.0g in 100mL over 10 to 20 minutes
-Maintenance infusion: 1-4gm/hour
-Reactive airway conditions: 2gm in 50mL over 5-10 min
-Cardiac arrest IV/IO: 1-2gm over 1-2 min

Question 9

Magnesium Sulfate PEDS dosage:

Answer 9

Reactive airway conditions infusion: 25-50 mg/kg of a 10% solution infused over 15-30 min; MAX DOSE: 2gm

Question 10

Methylprednisolone Trade name

Answer 10

Solu-Medrol®

Question 11

Methylprednisolone Classes:

Answer 11

-Corticosteroid
-Glucocorticoid
-Anti inflammatory

Question 12

Methylprednisolone Supply & Route:

Answer 12

-Vial
-IV/IO

Question 13

Methylprednisolone MOA:

Answer 13

-Suppresses acute and chronic inflammation
-Produces immunosuppressive effect
-Stabilizes cellular membranes

Question 14

Methylprednisolone Indications:

Answer 14

-Acute exacerbation of asthma, chronic bronchitis, emphysema, and other reactive airway conditions
-Anaphylaxis
-Burns involving the airway

Question 15

Methylprednisolone Contraindications:

Answer 15

None in the emergency setting

Question 16

Methylprednisolone S/E:

Answer 16

None for a single dose

Question 17

Methylprednisolone Onset:

Answer 17

1-6 hours

Question 18

Methylprednisolone Adult dosage:

Answer 18

125 mg

Question 19

Methylprednisolone PEDS dosage:

Answer 19

2.0-4.0 mg/kg