Lorazepam & Diazepam

Question 1

Lorazepam Trade Name:

Answer 1

Ativan

Question 2

Lorazepam Classes:

Answer 2

-Benzodiazepine
-Anticonvulsant
-Sedative
-Hypnotic

Question 3

Lorazepam Standard Supply:

Answer 3

Vial

Question 4

Lorazepam MOA:

Answer 4

-Produces sedation by acting on the limbic system, the thalamus, and cortex
-Binds to gamma-amino butyric acid (GABA) benzodiazepine receptors in the brain
-Raises the seizure threshold
-Produces tranquilizing (anti-anxiety) effect on the CNS

Question 5

Lorazepam Indications:

Answer 5

-Seizure activity
-Status epilepticus
-Procedural sedation for intubation and cardioversion
-Chemical restraint for agitated (excited) delirium
-Severe anxiety

Question 6

Lorazepam Contraindication:

Answer 6

Hypersensitivity

Question 7

Lorazepam S/E:

Answer 7

-Sedation
-Transient amnesia
-Respiratory depression
-Respiratory arrest
-Bradycardia
-Hypotension
-Dizziness
-Drowsiness
-Blurred vision
-Nausea/vomiting

Question 8

Lorazepam Routes:

Answer 8

IV
IO
IM

Question 9

Lorazepam Onset:

Answer 9

-IV/IO: 1-5 min
-IM: 15-30 min

Question 10

Lorazepam Adult Dosages:

Answer 10

-Seizure IV/IO: 2.0-5.0 mg over 2 min
-Seizure IM: 2.0-5.0 mg
-Procedural sedation IV/IO: 2.0 mg over 2 min
-Procedural sedation IM: 4.0 mg

*max dosage: 10 mg

Question 11

Lorazepam PEDS Dosages:

Answer 11

-Seizure IV/IO/IM: 0.05 to 0.1 mg/kg over 2 min
*max dosage 4.0 mg

Question 12

Diazepam Trade Name:

Answer 12

Valium

Question 13

Diazepam Classes:

Answer 13

-Benzodiazepine
-Anticonvulsant
-Sedative
-Hypnotic

Question 14

Diazepam Standard Supply:

Answer 14

-Vial
-Ampule

Question 15

Diazepam MOA:

Answer 15

-Produces sedation by acting on the limbic system, the thalamus, and hypothalamus
-Binds to gamma-amino butyric acid (GABA) benzodiazepine receptors in the brain
-Raises the seizure threshold
-Produces tranquilizing (anti-anxiety) effect on the CNS

Question 16

Diazepam Indications:

Answer 16

-Seizure activity
-Status epilepticus
-Procedural sedation for rapid sequence intubation and cardioversion
-Chemical restraint for agitated (excited) delirium
-Delirium tremens
-Severe anxiety

Question 17

Diazepam Contraindications:

Answer 17

-Hypersensitivity
-Head injury

Question 18

Diazepam S/E:

Answer 18

-Sedation
-Transient amnesia
-Respiratory depression
-Respiratory arrest
-Bradycardia
-Hypotension
-Dizziness
-Drowsiness
-Blurred vision
-Nausea, Vomiting

Question 19

Diazepam Routes:

Answer 19

IV
IO
IM
Rectal

Question 20

Diazepam Onsets:

Answer 20

-IV/IO: 2-5 min
-IM: 15-30 min
-Rectal: variable

Question 21

Diazepam Adult Dosages:

Answer 21

2.0 mg increments over 2 min

Question 22

Diazepam PEDS dosages:

Answer 22

-IV/IO: 0.2 - 0.3 mg/kg
-IM: 0.1 - 2.0 mg/kg
-Rectal: 0.2 - 0.5 mg/kg