Naloxone

Question 1

Brand Name for Naloxone

Answer 1

Narcan

Question 2

Drug Class of Naloxone

Answer 2

Opioid Antagonist, Antidote

Question 3

Indications for Naloxone

Answer 3

Opiate overdose
Complete or partial reversal of central nervous system and respiratory depression induced by opioids
Decreased LOC
Coma

Question 4

Mechanism of Action for Naloxone

Answer 4

Competitive inhibition at narcotic receptor sites
Reverse respiratory depression secondary to opiate drugs
Inhibits effect of morphine

Question 5

Contraindications for Naloxone

Answer 5

Use with caution in narcotic-dependent patients, neonates of narcotic-addicted mothers

Question 6

Adverse Effects of Naloxone

Answer 6

Restlessness
Seizure
Dyspnea
Pulmonary Edema
Tachycardia 
Hypertension 
Dysthymias
Cardiac Arrest
Nausea Vomiting
Diaphoresis

Question 7

Precautions for Naloxone

Answer 7

Incompatible with alkaline solutions

Acute withdrawal syndrome may result in a combative patient

Question 8

Dose & Administration of Naloxone

Answer 8

Adult Dose: 0.4-2 mg SIVP/IM/IO/SQ/ET/IN repeat at 5 minute intervals to max dose of 10mg
Pedi Dose: 0.1 mg/kg IV/IO/IM/SQ every 2 minutes as needed max dose of 2mg