Epinephrine

Question 1

Brand Name of Epinephrine

Answer 1

Adrenaline

Question 2

Drug Class for Epinephrine

Answer 2

Sympathomimetic

Question 3

Indications of Epinephrine

Answer 3

Cardiac Arrest
Symptomatic bradycardia refractory to atropine and pacing
Severe hypotension secondary to Bradycardia and pacing
Allergic reaction
Anaphylaxis
Asthma

Question 4

Mechanism of Action of Epinephrine

Answer 4

Alpha and Beta Agonist (some Alpha, more Beta)
Beta 1 (heart) = inotropic (strength), chronotropic (speed), dromotropic (conduction speed) Effects
Beta 2 (lungs) = Bronchial smooth muscle relaxation

Question 5

Contraindications for Epinephrine

Answer 5

Hypertension 
Hypothermia
Pulmonary Edema
Myocardial Ischemia 
Hypovolemic Shock

Question 6

Adverse Effects of Epinephrine

Answer 6

Nervousness 
Restlessness 
Headache 
Tremor
Pulmonary Edema 
Dysthymias
Chest Pain
Hypertension 
Tachycardia 
Nausea Vomiting
Anxiety

Question 7

Precautions for Epinephrine

Answer 7

Inactivated by exposure to sunlight and alkaline solutions
MAOI’s may potentiate Effects
Beta blockers will blunt effects

Question 8

Dose & Administration of Epinephrine

Answer 8

Allergic Reaction & Asthma: 0.3-0.5 mg IM/SC 1:1,000
Cardiac Arrest Adult: 1 mg 1:10,000 IV/IO q3-5 minutes
Bradycardia: 2-10 micrograms/minute infusion
Pedi Allergic Reaction: 0.01 mg/kg of a 1:1,000 IM/SC with max of 0.3 mg
Pedi Cardiac Arrest: 0.01 mg/kg of 1:10,000 q3-5 minutes max single dose 1mg