NALOXONE

Question 0

PHARMACOLOGY OF NALOXONE

Answer 0

Opioid antagonist

Question 1

PRESENTATION OF NALOXONE

Answer 1

0.4 mg in 1 mL glass ampoule

2 mg in 5 mL ( prepared synringe)

Question 2

ACTIONS OF NALOXONE

Answer 2

Prevents or reverses the effects of opioids

Question 3

PRIMARY EMERGENCY INDICATIONS FOR NALOXONE

Answer 3

Altered conscious state and respiratory depression secondary to administration of opioids or related drugs

Question 4

CONTRAINDICATIONS OF NALOXONE

Answer 4

Nil of significance in the OD setting

Question 5

PRECAUTIONS FOR NALOXONE

List all 2

Answer 5

1. If Pt is known to be physically dependent on opioids, be prepared for a combative Pt after administration
2. Neonates

Question 6

ROUTE OF ADMINISTRATION FOR NALOXONE

Answer 6

IM

IV

Question 7

SIDE EFFECTS OF NALOXONE

Answer 7

Symptoms of opioid withdrawal:

• sweating, goose flesh, tremor
• Nausea & Vomiting
• Agitation
• Dilatation of pupils, excessive lacrimation (tears)
• Convulsions

Question 8

ONSETS & DURATION OF NALOXONE

Answer 8

IV EFFECTS:
Onset: 1 - 3 min
Peak: n/a
Duration: 30 - 45 minutes

IM EFFECTS:
Onset: 1 - 3 min
Peak: n/a
Duration: 30 - 45 min

*Note: in the case of opioid associated cardiac arrest or head injury Naloxone should not be administered, just maintain ventilation if required,

Question 9

ADULT DOSE OF NALOXONE

Answer 9

IM 1.6 - 2 mg

Repeat @ 10/60 0.8mg if inadequate response

Question 10

PAEDIATRIC DOSE OF NALOXONE

Answer 10

10mcg/kg (Max 2mg)

Repeat @10/60 10mcg/kg if inadequate response