MIDAZOLAM

Question 0

PHARMACOLOGY OF MIDAZOLAM

Answer 0

Short acting CNS depressant

Question 1

PRESENTATION OF MIDAZOLAM

Answer 1

5 mg in 1 mL glass ampoule

15 mg in 3 mL glass ampoule

Question 2

ACTIONS OF MIDAZOLAM

Answer 2

Anxiolytic
Sedative
Anti-convulsant

Question 3

PRIMARY EMERGENCY INDICATIONS FOR MIDAZOLAM

List all 7

Answer 3

1. Continuous tonic-clonic seizures
2. Sedation to maintain intubation
3. Sedation to enable intubation
4. Rapid Sequence Intubation (RSI)
5. Sedation to enable cardioversion
6. Sedation in the agitated Pt
7. Sedation in psychostimulant OD

Question 4

CONTRAINDICATIONS FOR MIDAZOLAM

Answer 4

Known hypersensitivity to benzodiazepines

Question 5

PRECAUTIONS OF MIDAZOLAM

List all 4

Answer 5

1. Reduced doses may be required for the elderly, Pts with chronic renal failure, CCF or shock
2. The CNS depressant effects of benzodiazepines are enhanced in the presence of narcotics and other tranquillisers including alcohol
3. Can cause severe respiratory depression in Pts with COPD
4. Pts with myasthenia gravis (autoimmune neuromuscular disease)

Question 6

ROUTE OF ADMINISTRATION OF MIDAZOLAM

Answer 6

IM

IV

Question 7

SIDE EFFECTS OF MIDAZOLAM

Answer 7

Depressed level of conscioussness
Respiratory depression
Loss of airway control
Hypotension

Question 8

ONSET & DURATION OF MIDAZOLAM

Answer 8

IM
Onset: 3 - 5 min
Peak: 15 min
Duration: 30 min

IV
Onset: 1 - 3 min
Peak: 15 min
Duration: 20 min

Question 9

ADULT DOSAGE FOR MIDAZOLAM

Answer 9

TONIC-CLONIC SEIZURES:
60 yo 0.05 mg/kg IM (Max single dose 5mg)

Repeat @10/60 original dose of Midazolam once only if required

Question 10

PAEDIATRIC DOSE OF MIDAZOLAM

Answer 10

IM 0.1 mg/kg (Max single dose 10mg)

Repeat @ 10/60 once only if required