METOCLOPRAMIDE

Question 0

PHARMACOLOGY OF METOCLOPRAMIDE

Answer 0

Antiemetic

Question 1

PRESENTATION OF METOCLOPRAMIDE

Answer 1

10mg in 2mL polyamp

Question 2

ACTIONS OF METOCLOPRAMIDE

Answer 2

Accelerates gastric emptying and peristalsis

Dopamine receptor antagonist

Question 3

PRIMARY EMERGENCY INDICATION OF METOCLOPRAMIDE

List all 9

Answer 3

1. Nausea/Vomiting associated with
   - Chest pain / discomfort of a cardiac nature
   - Opioid administration for pain
   - Cytotoxic or radiotherapy
   - Previously diagnosed migraine
   - Severe gastroenteritis
2. Prophylaxis
   - Awake spinal immobilised Pts
   - Eye trauma

Question 4

CONTRAINDICATIONS OF METOCLOPRAMIDE

Answer 4

1. Gastrointestinal haemorrhage
2. Children
3. Suspected bowel obstruction or perforation

Question 5

PRECAUTIONS OF METOCLOPRAMIDE

List all 3

Answer 5

1. Adolescents (<20yrs)
2. Administer slowly over 1 min to minimise risk of extrapyramidal reactions
3. Undiagnosed abdominal pain

Question 6

ROUTE OF ADMINISTRATION FOR METOCLOPRAMIDE

Answer 6

IV

IM

Question 7

SIDE EFFECTS OF METOCLOPRAMIDE

Answer 7

Drowsiness
Lethargy
Dry mouth
Muscle tremor
Extrapyramidal reactions ( usually the dystonic type - muscle tremors)
( Extrapyramidal = various movement, dyskinesias, slurred speech (caused by dopamine blockade a.k.a dopamine antagonist))

Question 8

ONSET & DURATION OF METOCLOPRAMIDE

Answer 8

IV
Onset: 1 - 3 min
Peak: n/a
Druation: 10 - 30 min

IM
Onset: 10 - 15 min
Peak: n/a
Duration: 1 - 2 hr

Question 9

METOCLOPRAMIDE DOSE

Answer 9

N&V

10mg IV/IM -repeat @ 10/60 if symptoms persist (Max 20mg)