Mycoplasma Flashcards
Whats unique abt mycoplasma
no cell wall
sterols in cell membrane
What is the oxygen requirement for M. pneumonia? rest of Mycoplasma?
strict AEROBE
rest: facultative anaerobe
What binds glycoprotein receptors of base of cilia of epi cells? whats the result?
Terminal adhesion protein (p1)
ciliostasis – > destruction of ciliated epi cells –> upper airways don’t get cleared and LOWER resp tract becomes contaminated and irritated
M. pneumoniae acts as what? what does it stimulate?
super antigen
inflammatory cells for TNF, IL1,IL6 release
what is the common age group?
5-15 yo
Clinical syndromes
Mild URTI Otitis media tracheobronchitis Pneumonia Stevens-Jonhsons syndrome Erythema multiforme
How useful is micrscopes and cultures for diagnosis?
limited value - no cell wall
Best method for diagnosis?
Paired sera (IgM and IgG)
What might be useful to treat severe pulm disease, steven johnsons, encephalitis, hemolytic anemia
steroids