Chlamydia Flashcards
What type of organisms are Chlamydia
obligate intracellular
lack peptidoglycan layer
contain both DNA and RNA
What is the infectious form of chlamydia? is it active or inactive?
elementary bodies
inactive
What is the non infectious form of chlamydia? is it active or inactive?
Reticulate bodies
active
What does Reticulate bodies need to replicate
host cell’s ATP
What are inclusion bodies?
Phasomes containing replicating reticulate bodies
What are the two biovars of C. trachomatis?
Trachoma
LGV
What is the important structural component for C. trachomatis?
MOMP
What serologic variants of C. trachomatis are:
Trachoma: A-C
UG disease: D-K
LGV: L1-3
Receptors for EBs are restricted to:
nonciliated columnar, cuboidal, transitional epithelial cells
Why are LGV serovars more invasive?
replication within mononuclear phagocytes
Clinical manifestations of Chlamydia are caused by
direct cell destruction during replication
pro-inflammatory cytokine response they stimulate
what is the inflammatory resp for chlamydia
neutrophils
lymphocytes
plasma cells
Where do LGV form lesions?
LN with granuloma formation
what happens upon reinfection with chlamydia?
not immunity
vigorous inflammatory response and tissue damage – scarring, blindnes,, sterility, sexual dysfunction
Transmission of Trachoma
droplet, hand, clothing, flies
Which cell does chlamydia target in the cervix?
Columnar
–> squamous
What does chlamydia have a co-infection with?
HIV
What are the two phases of trachoma?
active trachoma - follicular conjunctivitis (tarsal)
cicatricial disease - scarring / blindness due to trichiasis
Trichiasis vs Pannus
Trichiasis: distorts lid margin, eyelash rubs on cornea
Pannus: growth of vascular tissue over cornea due to edema
What do you see in Chlamydia cervicitis?
Mucopurulent discharge
erythematous
friable
When is newborn inclusion conjunctiviitis acquired? symptoms?
during passage of infant through infected birth canal
swollen lids, hyperemia
purulent discharge
Reiter syndrome
urethritis
conjunctivitis
polyarthiritis
mucocutaneous lesions
C. trachomatis
young men
infant pneumonia due to Chlamydia
rhitinis
staccato cough
tacnypnea
interstitial infiltrates
Primary and secondary stage of LGV
primary: non painful lesion
secondary: inflammation and swelling of lymph nodes that drain the site of initial infection
most common nodes involved with LGV
inguinal
whats common in women with LGV, why?
Procitis
lymphatic spread from cervix or vagina
Parinaud oculoglandular syndrome
caused by LGV serotype
conjunctival inflammation with preauricular, submandibular and cervical lymphadenopathy
What should you culture or not culture for diagnosis of chlamydia ? why?
Don’t culture pus - pus = dead neutrophils – theyre intracellular organisms … or vagina - org found in columnar cells of cervix
CUlture urethra/cervix -live cells, not petridish
Pap smear is insensitive
What is the best lab diagnosis method?
NAAT
Best drugs for Chlamydia treatment in adults vs newborn
Azithromycin (1g po) or Dox for 7 days - 100 mg
Erythromycin 50 mg/kg/day for 14 days
What is a symptom associated with urethritis?
dysuria
