Chlamydia

Question 1

What type of organisms are Chlamydia

Answer 1

obligate intracellular
lack peptidoglycan layer
contain both DNA and RNA

Question 2

What is the infectious form of chlamydia? is it active or inactive?

Answer 2

elementary bodies

inactive

Question 3

What is the non infectious form of chlamydia? is it active or inactive?

Answer 3

Reticulate bodies

active

Question 4

What does Reticulate bodies need to replicate

Answer 4

host cell’s ATP

Question 5

What are inclusion bodies?

Answer 5

Phasomes containing replicating reticulate bodies

Question 6

What are the two biovars of C. trachomatis?

Answer 6

Trachoma

LGV

Question 7

What is the important structural component for C. trachomatis?

Answer 7

MOMP

Question 8

What serologic variants of C. trachomatis are:

Answer 8

Trachoma: A-C
UG disease: D-K
LGV: L1-3

Question 9

Receptors for EBs are restricted to:

Answer 9

nonciliated columnar, cuboidal, transitional epithelial cells

Question 10

Why are LGV serovars more invasive?

Answer 10

replication within mononuclear phagocytes

Question 11

Clinical manifestations of Chlamydia are caused by

Answer 11

direct cell destruction during replication

pro-inflammatory cytokine response they stimulate

Question 12

what is the inflammatory resp for chlamydia

Answer 12

neutrophils
lymphocytes
plasma cells

Question 13

Where do LGV form lesions?

Answer 13

LN with granuloma formation

Question 14

what happens upon reinfection with chlamydia?

Answer 14

not immunity

vigorous inflammatory response and tissue damage – scarring, blindnes,, sterility, sexual dysfunction

Question 15

Transmission of Trachoma

Answer 15

droplet, hand, clothing, flies

Question 16

Which cell does chlamydia target in the cervix?

Answer 16

Columnar

–> squamous

Question 17

What does chlamydia have a co-infection with?

Answer 17

HIV

Question 18

What are the two phases of trachoma?

Answer 18

active trachoma - follicular conjunctivitis (tarsal)

cicatricial disease - scarring / blindness due to trichiasis

Question 19

Trichiasis vs Pannus

Answer 19

Trichiasis: distorts lid margin, eyelash rubs on cornea

Pannus: growth of vascular tissue over cornea due to edema

Question 20

What do you see in Chlamydia cervicitis?

Answer 20

Mucopurulent discharge
erythematous
friable

Question 21

When is newborn inclusion conjunctiviitis acquired? symptoms?

Answer 21

during passage of infant through infected birth canal

swollen lids, hyperemia
purulent discharge

Question 22

Reiter syndrome

Answer 22

urethritis
conjunctivitis
polyarthiritis
mucocutaneous lesions

C. trachomatis
young men

Question 23

infant pneumonia due to Chlamydia

Answer 23

rhitinis
staccato cough
tacnypnea
interstitial infiltrates

Question 24

Primary and secondary stage of LGV

Answer 24

primary: non painful lesion
secondary: inflammation and swelling of lymph nodes that drain the site of initial infection

Question 25

most common nodes involved with LGV

Answer 25

inguinal

Question 26

whats common in women with LGV, why?

Answer 26

Procitis

lymphatic spread from cervix or vagina

Question 27

Parinaud oculoglandular syndrome

Answer 27

caused by LGV serotype

conjunctival inflammation with preauricular, submandibular and cervical lymphadenopathy

Question 28

What should you culture or not culture for diagnosis of chlamydia ? why?

Answer 28

Don’t culture pus - pus = dead neutrophils – theyre intracellular organisms … or vagina - org found in columnar cells of cervix

CUlture urethra/cervix -live cells, not petridish

Pap smear is insensitive

Question 29

What is the best lab diagnosis method?

Answer 29

NAAT

Question 30

Best drugs for Chlamydia treatment in adults vs newborn

Answer 30

Azithromycin (1g po) or Dox for 7 days - 100 mg

Erythromycin 50 mg/kg/day for 14 days

Question 31

What is a symptom associated with urethritis?

Answer 31

dysuria