Mutations and Translation

Question 1

Start codon

Answer 1

AUG

Codes for Methionine

Question 2

During elongation, ribosome moves in what direction

Answer 2

5’ to 3’ direction along the mRNA

Question 3

Nonsense mutation is

Answer 3

New codon is stop codon

Question 4

Large segment deletion is

Answer 4

unequal crossover in meiosis

Question 5

Examples in mutations in splice sites

Answer 5

Gaugher

Tay-Sachs

β-thalassemia

Question 6

Missense mutation is

Answer 6

new codon specifies different AA

Question 7

Frameshift mutation is

Answer 7

addition or deletion of bases

Question 8

A transversion is a point mutation that

Answer 8

replaces a purine-pyrimidine base pair with a pyrimidine-purine base pair

Question 9

Frameshift mutation affect

Answer 9

Unually nonfunctional

Often shorter than normal

Question 10

A transition is a point mutation that

Answer 10

replaces a purine-pyrimidine base pair with a different purine-pyrimidine base pair

Question 11

Codons are written in what direction

Answer 11

5’ to 3’

Question 12

Mannose residues are phosphorylated by

Answer 12

N-acetlyglucosamine-1 phosphotransferase

Question 13

Example of large segment deletion

Answer 13

α-thalassemia

Cri-du-chat

Question 14

Affect of missense mutations

Answer 14

decrease in function

variable affect

Question 15

Stop codons

Answer 15

UAA

UGA

UAG

Question 16

Major symptoms of I-Cell disease

Answer 16

1. Coarse facial features
2. Gingival hyperplasia
3. Macroglossia
4. Craniofacial abnormalitites
5. Joint immobility
6. Clubfoot
7. Claw-hand
8. Retardation
9. Growth retardation
10. Cardiorespiratory failure
11. Bone fracture and deformities
12. MV defects