Lipid synthesis and Storage

Question 1

What lipoprotein is elevated in Type 1 Hypertriglyceridemia

Answer 1

Chylomicrons

Question 2

Type 1 Hypertriglyceridemia is due to a deficiency in

Answer 2

Lipoprotein Lipase (rare)

apoC-2 (rare)

Question 3

Job of lipoprotein lipase

Answer 3

Removes fatty acid from chylomicron and VLDL

Question 4

What is the function of apoC-2

Answer 4

Activates lipoprotein lipase

Question 5

Type 1 Hypertriglyceridemia genetics

Answer 5

AD

Question 6

VLDL function

Answer 6

Transports TG from liver to tissue

Question 7

VLDL apoproteins

Answer 7

apoB-100

apoC-2

apoE

Question 8

Glycerol 3-P dehydrogenase converts

Answer 8

DHAP to Glycerol 3-P

Question 9

Type 2a hypercholesterolemia clinical

Answer 9

1. high risk of atherosclerosis and CAD
2. Xanthomas of the Achilles tendon
3. Tuberous xanthomas on elbows
4. Xanthelasmas
5. Corneal arcus

Question 10

LDL apoproteins

Answer 10

apoB-100

Question 11

Abetalipoproteinemia is due to deficiency in

Answer 11

apoB-100 and apoB-48

Question 12

Acetyl CoA carboxylase requires

Answer 12

Biotin

Question 13

What is the primary end product of FA synthesis

Answer 13

Palmitic acid (Palmitate)

Question 14

What lipid is elevated in Type 1 Hypertriglyceridemia

Answer 14

Triglycerides

Question 15

FA synthase converts

Answer 15

Malonyl CoA to FA palmitate

Question 16

Function of Chylomicrons

Answer 16

Transport dietary TG and cholesterol from intestine to tissue

Question 17

What does LCAT do

Answer 17

adds a FA to cholesterol producing Cholesterol esters

Question 18

Type 2a hypercholesterolemia genetic

Answer 18

AD

Question 19

Lipid elevated in Type 2a hypercholesterolemia

Answer 19

Cholesterol

Question 20

What are the two sources of Glycerol 3-P

Answer 20

1. Reduction of DHAP from glycolysis by glycerol 3-P
2. Phosphorylation of free glycerol by glycerol kinase

Question 21

Chlyomicron apoproteins

Answer 21

apoB-48

apoC-2

apoE

Question 22

Type 1 Hypertriglyceridemia clinical

Answer 22

Red-orange eruptive xanthomas

Fatty liver

Acute pancreatitis

Abdominal pain after fatty meal

Question 23

What is needed for the synthesis of Triglycerides

Answer 23

Glycerol 3-P

Question 24

LDL function

Answer 24

Delivers cholesterol into cell

Question 25

IDL function

Answer 25

picks up cholesterol from HDL to become LDL

Question 26

FA synthase requires

Answer 26

NADPH

Question 27

Type 2a hypercholesterolemia deficiency in

Answer 27

LDL-receptor

Question 28

Lipoprotein elevated in Type 2a hypercholesterolemia

Answer 28

LDL

Question 29

Two important essential FA

Answer 29

Linolenic acid Linoleic acid

Question 30

HDL apoprotein

Answer 30

apoA-1

Question 31

HDL function

Answer 31

1. Picks up cholesterol accumulating in BV 2. Delivers cholesterol to liver and steriodogenic tissues via **scavenger receptor (SR-B1)** 3. Shuttles apoC-2 and apoE in blood

Question 32

Malic enzyme converts

Answer 32

Malate to pyruvate Increase NADPH

Question 33

LCAT activated by

Answer 33

apoA-1

Question 34

What does fatty acyl CoA synthetase do

Answer 34

Attach CoA to FA

Question 35

Triglycerides are formed by

Answer 35

Attaching 3 FA to Glycerol

Question 36

Acetyl CoA carboxylase converts

Answer 36

Acetyl CoA to Malonyl CoA

Question 37

IDL apoproteins

Answer 37

apoE apoB-100

Question 38

Abetalipoproteinemia clinical

Answer 38

1. Steatorrhea 2. Cerbellar ataxia 3. Pigmentary degeneration in the retina 4. Acanthocytes (**thorny appearing erythrocytes**) 5. Loss of night vision