Citric Acid Cycle and Oxidative Phosphorylation

Question 1

What enzymes yields energy in Citric Acid Cycle

Answer 1

1. Isocitrate dehydrogenase (NADH)
2. α-Ketoglutarate (NADH)
3. Succinyl-CoA (GTP)
4. Succinate dehydrogenase (FADH₂)
5. Malate dehydrogenase (NADH)

Question 2

Isocitrate dehydrogenase is inhibited by

Answer 2

NADH and ATP

Question 3

Mitochondrial Diseases

Answer 3

1. Leber hereditary optic neuropathy
2. MELAS:
   
   1. Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes
3. Myoclonic epilepsy
   
   1. Ragged red muscle fibers

Question 4

Other than Citric Acid Cycle, what is the role of Succinyl-CoA

Answer 4

Heme synthesis

Question 5

Succinyl-CoA synthetase converts

Answer 5

Succinyl-CoA to Succinate

Question 6

α-Ketogluarate requires

Answer 6

Tender Love Care For Nancy:

T: Thiamine

L: Lipoic acid

C: Coenzyme A

F: FAD

N: NAD

Question 7

Overall result of Citric Acid Cycle

Answer 7

3 NADH

FADH₂

GTP

Question 8

Isocitrate dehydrogenase converts

Answer 8

Isocitrate to α-Ketoglutarate

Question 9

ATP Synthase of ETC inhibited by

Answer 9

Oligomycin

Question 10

Citrate synthase converts

Answer 10

Oxaloacetate with Acetyl-CoA to form Citrate

Question 11

Complex 4 of ETC inhibited by

Answer 11

Cyanide

CO

Question 12

Complex 1 of ETC inhibited by

Answer 12

Barbiturates

Rotenone (insecticide)

Question 13

Where are the enzymes of Citric Acid cycle located

Answer 13

Matix of Mitochondria EXCPET Succinate dehydrogenase (Located in the inner membrane)