Muscle structure Flashcards
Based on Yeo lectures. Basics of muscular structure
What are the three types of muscle?
Smooth, cardiac, skeletal
What is the definition of contraction?
The active state of muscle generating tension
What are the three types of contraction?
Isometric (no length change), concentric (shortening), and eccentric (lengthening)
What is the definition of tension?
A pulling force exerted by each end of muscle
What is the hierarchy of muscle?
Actin + myosin filaments Sarcomeres Myofibril Fibers Fascicles Muscle Compartments
Outline the sliding filament theory
A.p. along sarcolemma Down t-tubules To SR Ca2+ released Bind to troponin Tropomyosin moved aside Myosin head binds to actin (cross-bridges) Myosin head moves backwards • - ADP + Pi released Actin filament pulled past myosin ATP to myosin head Cross-bridges hydrolysed • - ATP --> ADP + Pi Myosin head moves to original position
What are fibers covered in?
Endomysium, which carries capillaries and the nerves that innervate each fiber
What are fasicles covered in?
Peromysium, which protects muscle fibres and provides pathways for nerves and blood vessels
What are muscles covered in?
Epimysium, which transfers tensions to the tendon
What are compartments separated by?
Fascia, which is a sheet of fibrous tissue
How is force transferred?
The contractile fibres generate tension, applying force to both ends. This force is gathered in tension and the resultant force pulls bone, transferring force from fibre to bone
What is the name of the point at which tendon connects to muscle?
Musculo-tendinous junction
What is the name of the point at which tendon connects to bone?
Teno-osseous junction
What is the composition of tendons?
Consist of collagen fibres arranged parallel to force application of muscle
What is an aponeurosis?
A sheet of fibrous tissue taking the place of a tendon in sheet-like muscles with a wide area of attachment
What are the two different types of fibres?
Parallel and penniform
What is the indicative feature of penniform fibres?
The fibres run diagonally to tendon
What is a physiological cross-sectional area?
The cross-section of muscle perpendicular to fibres; the sum total of all of the cross sections of fibers in the muscle in the plane perpendicular to the direction of the fibers
Which fibre has a smaller PCSA?
Parallel fibres, meaning it is weaker
Which fibre is slower to contract?
Penniform, as fibres must shorten more for the same length of contraction
What type of connective tissue is normally present for penniform fibres?
Aponeurosis
What are the the three types of penniform fibres?
Uni, bi, multi-pennate
What is the pennation angle?
The angle made by fascicles and the line of action of the muscle
What is the significance of having a greater pennation angle?
Smaller force is transmitted. The angle also increases with contraction
What are the different types of parallel fibres?
Flat, fusiform, strap, convergent, circular
How do you calculate muscle volume?
MV = m/(density)
How do you calculate CSA?
CSA = MV/L
How do you calculate PCSA?
mcos(theta)/(density)L
What is the Contractile Component of the Hill-type muscle?
Active force generated by x-bridges; fibres
What is the Parallel Elastic Component?
Inside of sarcomere, the passive force in parallel with the CC; connectin
What is the Series Elastic Component?
Outside of sarcomere, can change length independent of x-bridges; shock absorption; tendons
What are Type 1 fibres?
Slow-twitch; oxidative
What are Type 2a fibres?
Inter-mediate; oxidative-glycolytic
What are Type 2b fibres?
Fast-twitch; glycolytic
What are features of skeletal muscles?
Striated, multinucleate, and unbranched
What is smooth muscle used for?
To push something; blood flow, peristalsis, and child birth
What are features of cardiac muscle?
Have intercalated discs (interdigitations), and is branched