Muscarinic antagonists (M blockers)

Question 1

Pharmacological effects

Answer 1

Decreased secretions -> Dry mouth
Mydriasis and cycloplegia
Hyperthermia (with vasodilation) 
Tachycardia
Sedation
Urinary retention and constipation
Behavioral exitation and hallucination

Question 2

Atropine

Answer 2

Management of AchE inhibitor overdose

Antispasmodic, Antisecretory, Antidiarrheal, opthalmology (but long action) (pre-anestesia)

Question 3

Tropicamide

Answer 3

Opthalmology

Question 4

Ipratropium

Answer 4

Asthma and COPD (inhalational)

Question 5

Scopolamine

Answer 5

CNS entry, via oral
Used in motion sickness, cause sedation and short-term memory block (Anterograde amnesia)
(bradiarrithmias)

Question 6

Benztropine

Trihexyhenidyl

Answer 6

CNS entry

Used in parkinsonism and acute extrapyrimidal symptoms induced by anti-psychotics

Question 7

Contraindicaciones

Answer 7

Miastenia Gravis
Obstrucción GI/GU
Hipertrofia prostatica benigna
Glaucomas

Question 8

Other drugs with antimuscarinic pharmacology:

Answer 8

Antihistamines
Tricyclic antidepressants
Antipsychotics
Quinidine - antiarritmicos
Amantadine - antiviral medication
Meperidine - opiate

Question 9

Interacciones

Answer 9

Antihistamines
Antidepresivos triciclicos
Neurolepticos clasicos
IMAOs
Fenotiazina (antiepileptico)