Muscarinic agonists

Question 1

Bethanecol

Answer 1

M
Not hydrolyzed by AChE
Treatment ileum (gut not moving) postop/neurogenic
Urinary retention
(GERD)

Question 2

Methacholine

Answer 2

M>N
Hydrolyzed by AChE
Diagnosis of bronchial hyper reactivity

Question 3

Pilocarpine

Answer 3

M
Not hydrolyzed by AChE
Enters CNS
Treatment of glaucoma (topical) and xerostemia (sjogren)

Question 4

Direct acting muscarinic agonists:

Answer 4

Ach
Bethanecol
Methacoline
Pilocarpine
(Carbacol) - Not hydrolyzed, M & N - Glaucoma

Question 5

Indirect acting cholinomimetics = Acetylcholinesterase inhibitors

Answer 5

Edrophonium
Physostigmine
Neostigmine
Pyridostigmine
Donepezil
Tacrine
Organo Phosphates

Question 6

Edrophonium

Answer 6

Diagnosis myastenia
IV
Used to differentiate myasthenia from cholinergic crisis
Short acting

Question 7

Physostigmine

Answer 7

Enters CNS
Tertiary amine
Oral
Treatment of glaucoma
Antidote in atropine overdose

Question 8

Neostigmine, Pyridostigmine

Answer 8

Treatment ileus, urinary retention, myastenia (long lasting)
Reversal of non depolarizing NM blockers
IV
Cuartiary amines

Question 9

Donepezil, Tacrine

Answer 9

CNS entry
Oral
Treatment of alzheimer disease

Question 10

Organo phosphates

Answer 10

Irreversible inhibitors
Treatment glaucoma (ecothiopate)

Question 11

Agonistas sinteticas selectividad M1

Answer 11

Oxotremorina

Xanomelina

Question 12

Contraindicaciones

Answer 12

Ulceras pepticas
IC
Asma
Epilepsia (pilocarpina)

Question 13

Insecticides

Answer 13

Malathion, Parathion

paraxón

Question 14

Nerve gas

Answer 14

Sarin

somán, tabín