Muscarinic Antagonists

Question 1

Muscarinic antagonists are also called?

Answer 1

Cholinergic antagonists

Question 2

What is the MOA for muscarinic antagonists?

Answer 2

Competitive antagonists for endogenous acetylcholine at muscarinic receptors

Question 3

What effect do muscarinic antagonists have on the lungs?

Answer 3

Inhibits vagal mediated constriction of smooth muscle and mucous production

Question 4

What are the available routes of administration for muscarinic antagonists?

Answer 4

Inhaled
Nebulized

Question 5

What are the different dosing regimens for muscarinic antagonists?

Answer 5

SAMAs (3-4 x daily)
LAMAs (1x daily)

Question 6

What is a drug interaction of muscarinic antagonists?

Answer 6

Inhibits CYP1A2

Question 7

Muscarinic antagonists are generally well tolerated but what are possible ADEs?

Answer 7

Xerostomia
Bitter taste
Urinary retention

Question 8

What are indications for use for SAMAs?

Answer 8

PRN for asthma treatment
Px w/ asthma + COPD overlap
“Reliever” med

Question 9

What are indications for use for LAMAs?

Answer 9

COPD
Severe asthma w/ hx of exacerbations
“Controller” med

Question 10

Is ipratropium a SAMA or a LAMA?

Answer 10

SAMA

Question 11

“Most” muscarinic antagonists end in?

Answer 11

-ium

Question 12

LAMAs should not be used for?

Answer 12

Tx of acute asthma attacks

Question 13

What happens if muscarinic antagonists are d/c in a px?

Answer 13

Slight rebound of symptoms