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Pharm: Asthma/COPD > Methylxanthine > Flashcards

Methylxanthine Flashcards

1
Q

What is the single methylxanthine agent?

A

Theophylline

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2
Q

Methylxanthines are?

A

Bronchodilators
Immunomodulators

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3
Q

How do methylxanthines cause bronchodilation?

A

Nonselective inhibitor of phosphodiesterase (increase cAMP)
Adenosine receptor antagonist (inhibits adenosine from releasing histamine and leukotrienes that cause bronchodilation)

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4
Q

What is theophyllines route of administration?

A

Oral

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5
Q

What is the dosing frequency of theophylline?

A

Once daily

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6
Q

Methylxanthines are a substrate of?

A

CYP1A2 and CYP3A4

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7
Q

Methylxanthines have

A

MANY drug interactions

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8
Q

What are the ADEs of methylxanthines?

A

HA, N/V

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9
Q

When/why are methylxanthines used?

A

Add on treatment in asthma

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10
Q

Methylxanthines have a _____________________ which means?

A

Narrow therapeutic window
Must monitor drug concentration levels when used long term

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Pharm: Asthma/COPD (11 decks)

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