Corticosteroids Flashcards
Corticosteroids end in
-ide
-one
Corticosteroid MOA
Bind to glucocorticoid receptors which inhibit inflammatory cascade
Most common route of administration for corticosteroids?
Inhaled
What route of administration is used for exacerbations for corticosteroids?
Oral
When is the IV route of administration used for corticosteroids?
Severe exacerbations
Status asthmaticus
Corticosteroids dosing frequency
Once or twice daily
What is the drug interaction of corticosteroids?
Can decrease effectiveness of diabetic medications
Raises blood glucose (glucocorticoid) and inhibits insulin
ADEs of oral/IV corticosteroids
Suppression of HPA axis
Increased blood sugar
ADEs of inhaled corticosteroids
Hoarseness
Cough
Oropharyngeal candidiasis (thrush)
Px’s with COPD taking inhaled corticosteroids are at increased risk of?
Pneumonia
Corticosteroids are the backbone of treatment for?
Asthma
In which patients are corticosteroid use indicated?
COPD px w/
Hx of hospitalizations
1+ moderate exacerbations per year
Elevated eosinophil counts
Overlap syndrome
Prednisone, prednisolone, and methylprednisolone are administered via which route and are used to tx what condition?
Oral
Asthma tx only
How are oral steroids prescribed for severe exacerbations?
Short bursts
No taped is needed with corticosteroids when the duration is less than?
10-14 days
Oral corticosteroids are given as a?
Single dose in the morning
If the px cannot tolerate GI side effects, how can oral steroids be given?
In multiple doses as opposed to single dose
Which inhaled corticosteroid has the highest oral availability?
Beclomethasone
Which inhaled corticosteroids have the fewest systemic side effects with high doses?
Fluticasone proprionate
Budesonide
Which inhaled corticosteroid has once daily dosing?
Fluticasone furoate
How can a px decrease their risk of thrush when using inhaled corticosteroids?
Wash mouth out after use
Use a spacer
What are three factors to selecting a corticosteroid agent for a px?
Insurance
Inhaler type
Frequency
Are there any clinical differences between inhaled corticosteroid agents in asthma vs. COPD?
No
