Leukotriene Receptor Antagonists

Question 1

Leukotriene receptor antagonists end in what suffix?

Answer 1

-lukast

Question 2

Leukotriene receptor antagonists are also known as?

Answer 2

Leukotriene modifiers

Question 3

What is the MOA of LTRA?

Answer 3

Antagonize cysteinyl LT-1 receptors

Question 4

What actions do cysteinyl LTs regulate?

Answer 4

Plasma exudation
Mucus secretion
Bronchoconstriction
Eosinophil recruitment

Question 5

How are LTRAs administered?

Answer 5

Orally

Question 6

What is the dosing frequency of LTRAs?

Answer 6

Once or twice daily

Question 7

What does Zafirlukast inhibit?

Answer 7

CYP2C8
CYP2C9
CYP3a4

Question 8

LTRAs are typically _______________ except for which two?

Answer 8

Well-tolerated
Except Zafirlukast and Montelukast

Question 9

What are the ADEs of Zafirlukast?

Answer 9

Elevate liver enzymes
HA, dyspepsia

Question 10

What is Montelukast’s BBW?

Answer 10

Serious mental health problems
Agitation, depression, sleep disturbances, suicidal ideation

Question 11

Montelukast and Zafirlukast can cause what syndrome?

Answer 11

Churg-Strauss Syndrome/ EFPA

Question 12

What is the indication for use of LTRAs?

Answer 12

Asthma

Question 13

Leukotriene modifiers can also be used for what condition?

Answer 13

Allergic rhinitis