5-Lipoxygenase Inhibitors

Question 1

5-lipoxygenase inhibitors are also classified as a?

Answer 1

Leukotriene modifier

Question 2

What is the one 5-lipoxygenase inhibitor agent?

Answer 2

Zileuton (Zyflo CR)

Question 3

What is Zileuton’s MOA?

Answer 3

Selectively and specifically inhibits 5-lipoxygenase, inhibits synthesis of cysteinyl LTs

Question 4

How is Zileuton administered?

Answer 4

Orally

Question 5

What is the dosing frequency of Zileuton Immediate release?

Answer 5

4x a day

Question 6

What is the dosing frequency of Zileuton extended release and what is a consideration when taking this medication?

Answer 6

2x a day
Taken 1 hr after meals

Question 7

5-lipxygenase inhibitors are highly?

Answer 7

Protein bound

Question 8

Why does Zileuton ER have to be taken 1hr after meals?

Answer 8

Absorption is impaired by food

Question 9

What is the drug interaction of Zileuton?

Answer 9

Inhibits CYP1A2

Question 10

What are the ADEs of Zileuton?

Answer 10

Elevate hepatic enzymes
HA, dyspepsia

Question 11

What are the indications for use of Zileuton?

Answer 11

Asthma