Beta-2 Agonists

Question 1

Beta-2 agonists end in?

Answer 1

-terol

Question 2

What is the MOA for beta-2 agonists?

Answer 2

Bind to beta-2 receptors
Activates conversion of ATP to cyclic AMP via adenyl cyclase, which increases phosphokinase A

Question 3

Beta-2 agonists inhibit bronchodilation or bronchoconstriction?

Answer 3

Inhibits bronchoconstriction

Question 4

How do beta-2 agonists inhibit bronchoconstriction?

Answer 4

Directly relax smooth muscle in lungs
Inhibits release of bronchoconstrictor mediators from inflammatory cells

Question 5

What are the two routes of administration for beta-2 agonists?

Answer 5

Inhaled
Nebulized

Question 6

What are the two dosing regimens for beta-2 agonists?

Answer 6

SABAs: 3-4x a day
LABAs: 1-2x a day

Question 7

What are the most common ADEs of beta-2 agonists?

Answer 7

Tachycardia
Palpitations

Question 8

What are less common ADEs of beta-2 agonists?

Answer 8

Hyperglycemia
Hypokalemia
Hypomagnesemia
Skeletal muscle pain
Tremors

Question 9

What are indications for use of beta-2 agonists?

Answer 9

Quick relief of asthma/COPD symptoms
Prevention of exercised-induced asthma symptoms
Asthma/COPD controller

Question 10

SABA agents, onset, and duration

Answer 10

Albuterol, Levalbuterol
Onset = 5-15 min
Duration = 3-6 hrs

Question 11

LABA agents with 12 hr duration

Answer 11

“SIO” (salmeterol, indacaterol, olodaterol)

Question 12

What is important about vilanterol?

Answer 12

Once daily dosing
Only available in combo inhalers

Question 13

Formoterol: Class, onset, duration

Answer 13

LABA
Rapid onset, long-acting (12 hrs)

Question 13

Beta-2 agonists have no ________________ effect

Answer 13

Anti-inflammatory