Multiple Sclerosis

Question 1

complications with human brain tissue

Answer 1

lack of pathologists
no economic incentive for postmortem diagnosis

Question 2

oligodendrocytes

Answer 2

make up myelin sheath
of about five neurons

Question 3

microglia

Answer 3

clear debris and catse inflammation

Question 4

NG2 cells

Answer 4

= polydendrocytes
precursors to oligodendrocyte
potential target in MS

Question 5

PVS

Answer 5

= perivascular space
between endothelial and astrocytes
T cells accumulate here at tight junctions

Question 6

two-stage idea of MS

Answer 6

most likely wrong
because inflammation occurs throughout whole disease

Question 7

sphingolipids in MS

Answer 7

altered metabolism
pull apart myelin sheaths
elongate nodes of Ranvier
makes phagocytosis of myelin quicker

Question 8

theories on MS

Answer 8

inside out: axon goes wrong, immune system steps in
outside in: Epstein Barr virus

Question 9

G ratio

Answer 9

the bigger the axon the smaller the myelin

Question 10

microglia nodule

Answer 10

four or five microglia knotted together
found somewhat in strokes
a lot in MS
form to clear up oxidised lipids