Multiple scleorsis Flashcards
MS
Chronic Demyelinating inflammatory progressice autoimmune
Prevelance
temperate latitude 20-40 yrs old higher socio-economic groups genetic element caucasian
S&S
visual acuity dipolpia fatigue weakness spasticity and hyperreflexia ataxia poor communication sensory loss- parasthesia tingling burning dizziness poor balance sphincter disturbance sexual dsyfunction psychiatric decreased intellectual function
Initial Symptoms
limb weakness optic neuritits parasthaesia dipolpia vertigo micturition problems- urination retenriton
Types
relapsing-remitting MS
primary progressive MS
secondary progressive MS
benign MS
Pathology
distribution of blood brain barrier
leakage of inflammatory cells
destruction of olgiodendrocytes and myelin sheath
disruption of nerve signal
Triggers
infection vaccination pregnancy trauma emotional stress
environmental factor
viral factor
genetic factor
deficiencies in diet
Hypothese
MS is product of both environmental & genetic
factors. Exposure to some environmental agent
during childhood, in those genetically susceptible,
results in auto-immune response
Or is the inflammation a response to underlying
axonal degeneration
Treatment of symptoms
- Disease modifying drugs
- Anti-spasticity agents and relaxants
- Anti-depressants
- Analgesia
- Drugs to reduce bladder problems
- Splinting
- Wheelchairs and seating
- Diet - linoleic acid, fish oils, vitamin D
- Hyperbaric oxygen
- Physiotherapy
Rehabilitation
Develop improved strategies of movement
relearn motor skills
improve quality of patterns of movement
minimize abnormalities of muscle tone
emphasise functional application of Rx
support to maintain motivation and participation
implement strategies to prevent contractures
maintain/improve fitness/prevent deconditioning
education