Mucosal Immunity Flashcards
Two semi-autonomous parts of the human immune system
Systemic immune system, mucosal immune system
Inductive compartments
Secondary lymphoid tissue, where antigen active an acquired immune respons
What programs homing of B and T cells back to the mucosa?
Retinoic acid
Three dominant cytokines in mucosal immunity and type
TGF-β, Il-10, retinoic acid. Anti-inflammatory
Secrete TGF-β
Epithelial cells, iTreg
Secrete Il-10
iTreg, mucosal macrophages
Transfer of Ab-mediated immunity through nursing
Secretory IgA
Goblet cells
Innate defense, secretes mucus.
Mucus
Sugars that tether secretory IgA and IgG, defensins and antimicrobial peptied.
Epithelial cells, innate defense
Tight junctions and secretes TGFβ. If infection.
Epithelial cells; infection
Secretes defensins, antimicrobial peptides. Chemokines recruits neutrophils, monocytes. Secretes Il-1 and Il-6.
Paneth cells
Makes definsins and lysozyme that keeps crypts sterile.
Butyrate
Left over from microbiotic digestion of mucus. Feeds cells and triggers Il-22 production, stimulating mucus and tight junctions. Triggers RA from intestinal DCs.
Dysbiosis
Happens when normal microbiota is disturbed by disease or antibiotics.
Mucosal macrophages
Produce Il-10, don’t express inflammatory FcRs, don’t migrate. Functions to phagocytose commensal microbiota.
