Cancer Immunology & Immunotherapy

Question 1

Long-term survival often correlated with

Answer 1

Intratumoral CD3 or CD8 T-cells with IFN gamma producing phenotype

Question 2

How does T cells eliminate tumors?

Answer 2

CTLs

Question 3

Innate immunity against tumors

Answer 3

Mediated by NK cells.

Question 4

Requirement for T-cell activation

Answer 4

Danger signals in form of PAMPs and co stimulatory factors on APCs

Question 5

T-cells can be prevented in eliminating tumor because of…

Answer 5

Tolerance

Question 6

NK cells can be activated using

Answer 6

PAMPS

Question 7

DCs as vaccine delivery system

Answer 7

DC gets loaded with tumor antigens

Question 8

Transfection of tumor cells

Answer 8

Tumor cells get transfected with B7 in order to activate CD8 cells against tumor antigen.

Question 9

Intracellular pathogens

Answer 9

Virus can get tumor cells to screte GM-CSF, stimulating maturation and migration of DCs.

Question 10

Antibody-mediated approaches

Answer 10

Toxin delivery, radioactivity, binding to Fc receptors on NK cells.