Immunodeficiencies

Question 1

Disease progression without innate immunity

Answer 1

Rapid increase of microorganisms

Question 2

Disease progression without adaptive immuty

Answer 2

Initial control of organism no. followed by increasing no. of microorganisms.

Question 3

Innate eliceted response

Answer 3

Inflammation in infected tissue causes swelling, redness heat and pain.

Question 4

Complement

Answer 4

Attaches to pathogen, opsonizes.

Question 5

Mutations causing defect in innate immunity

Answer 5

Mutations in TLR or signaling components. Mutations in complement

Question 6

Mutations causing defect in innate immunity

Answer 6

Muations in MHC, TCRs or BCRs

Question 7

Primary immunodeficiency

Answer 7

Genetic cause

Question 8

Acquired immunodeficiency

Answer 8

Can be result of infection, environment or drugs

Question 9

How does MHC heterogeneity affect susceptibility to infectious disease?

Answer 9

Heterogeneity results in smaller suceptibility

Question 10

Pathogen specific immunodeficiency

Answer 10

Pathogens can alter their antigens to evade immune response

Question 11

Flu immune evasion

Answer 11

Genetic drift/shift

Question 12

Trypanosome evasion

Answer 12

Different types of VSG are expressed at different times during infection

Question 13

Mechanism of VSG variation

Answer 13

Gene conversion moves different VSG genes into the site for expression

Question 14

SSLP7 mechanism of immune evasion

Answer 14

Protein that binds C5 and IgA, preventing both MAC attack and IgA-mediated phagocytosis.

Question 15

Dominant inhibitor alleles

Answer 15

Heterodimers of receptors can result in dominant loss of function mutations.

Question 16

Sex-linked

Answer 16

Mutatations affecting immune response on X-chromosome.