Mucosal and Dermal immunity Flashcards
Systemic Immune Response
no-local
What types of tissue are involved in Mucosal and Cutaneous Immunty
Mucosa and skin associated Lymphoid tissue
What makes up the Mucosa-associated Lymphoid tissue
GALT, BALT, NAlt
Relatively thin layers of Epithelial cells that line body passages
Mucosa
Surface area of Mucosa
400 square meters
Single Later of columnar Epithelial cells
Type I mucosa
Many layers, with top being squamous epithelial cells
Type II mucosa
Viscous solution of polysaccharides mixed with water
Mucus
What does Mucus cover
Apical membrane of epithelial cell
Mucus contains
Antimicrobial peptides, enzymes, antibodies…
Main Ab of Type I mucus
SIgA
Main Ab of Type II mucus
IgG
Non-inducible Defenses of GI
Acidity, Motility, Mucous Layer with under glycocalyx, Tight Junction
Where commensal bacteria for the gut hang out
in the lumen
What is found in the emithelial layer of the Gut
Intra-epithelial lymphocytes(gamma delta T cells), Goblet cells(mucus) and Paneth cells (for antimicrobial peptides)
M Cell roll in Gut
Antigen sensing
Where Imune cells are found in the gut
In the Lamina Proprea
Firs cells to touch Pathogen
Intestinal Epithelial cells
Area under the epithelial cells
Lamina Propria
Lamina Propria contain
Macrophages, neutrophils, mast cells, immature DCs, Memory T and B cells, effector Th17 cells
Cell involved with Pyer’s patches in the gut for an immune response
M cell
Ag Sampling in the gut
M cells internalize to give to Dendritic cells
CD103 DC’s-elongate through epithelial layer to sample lumen
NALT and BALT provide defense against
Inhaled AG
NALT involves
Nasal submucosal glands, Tonsils, Epithelial Cells(type II), Follicles and Diffuse Lymphocytes