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Formulary > MSK > Flashcards

MSK Flashcards

1
Q

Paracetamol: Action

A

Non-opioid

COX-2 inhibitor

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2
Q

Paracetamol: Indications (2)

A

Acute/chronic pain (1st line)

Fever

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3
Q

Paracetamol: Contraindications

A

Decrease dose in liver toxicity

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4
Q

Paracetamol: Side Effect

A

Liver failure (give acetylcysteine)

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5
Q

Paracetamol: Interaction

A

P450 inducers increase liver damage

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6
Q

Diclofenac: Action

A

NSAID
COX inhibitor => inhibit prostaglandin synthesis
COX-1- renal perfusion, anti-thrombus => SE
COX-2- inflammation and pain

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7
Q

Diclofenac: Indications (2)

A

Mild-mod pain

Inflammatory pain

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8
Q

Diclofenac: Contraindications (2)

A

Renal impairment

Peptic ulcer disease

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9
Q

Diclofenac: Side Effects (2)

A

Renal impairment

Increase risk of CV events

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10
Q

Diclofenac: Interactions (2)

A

Increased ulceration/bleed w aspirin, corticosteroids, anticoags, SSRIs
Increased renal impairment with ACEi. diuretics

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11
Q

Codeine: Action

A

Opiate

Metabolised in liver => morphine

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12
Q

Codeine: Indication

A

Mild to mod pain

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13
Q

Codeine: Contraindication

A

Uncontrolled epilepsy (tramadol)

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14
Q

Codeine: Side Effects (2)

A

Constipation

Neuro/respiratory depression

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15
Q

Morphine: Action

A

Opioid
Activate opioid u receptor => decrease neuronal excitability and pain transmission
Decrease hypoxia/hypercapnia response

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16
Q

Morphine: Indications (2)

A

Acute severe pain

Breathlessness at end of life

17
Q

Morphine: Contraindication

A

Biliary colic

18
Q

Morphine: Side Effects (3)

A

Respiratory depression
Pupil constriction
Constipation

19
Q

Allopurinol: Action

A

Xanthine oxidase inhibitor

Lower plasma uric acid and precipitation in joints/kidneys

20
Q

Allopurinol: Indications (2)

A

Prevent gout

Prevent uric acid/calcium oxalate renal stones

21
Q

Allopurinol: Contraindication

A

Do not start in acute gout attack

22
Q

Allopurinol: Side Effect

A

Rash

Formulary (9 decks)

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