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Formulary > Neuro drugs > Flashcards

Neuro drugs Flashcards

1
Q

Levodopa: Action

A

Dopamine precursor

Cross blood-brain barrier to excite motor cortex

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2
Q

Levodopa: Side Effects (5)

A 
Nausea
Drowsiness
Confusion
Hypotension
Hallucination
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3
Q

Levodopa: Interactions (2)

A

Always given with a peripheral dopa-decarboxylase inhibitor

Contraindicating effects with antipsychotics and metoclopramide

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4
Q

Phenytoin: Action

A

Anticonvulsant

Bind to neuronal Na channels => prolong inactivity => inhibit seizure spread

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5
Q

Phenytoin: Indications (2)

A

Control seizures in status epileptics

Reduce seizure frequency in epilepsy

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6
Q

Phenytoin: Contraindications (2)

A

SA block

Pregnancy

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7
Q

Phenytoin: Side Effects (4)

A

Change in appearance
Cerebellar toxicity
Impaired cognition and consciousness
Haematological disorders

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8
Q

Phenytoin: Interactions (2)

A

P450 inducer

Efficacy reduced by SSRI, tricyclics and antipsychotics

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9
Q

Carbamazepine: Action

A

Inhibit neuronal Na channels => stabilise resting potentials and reduce excitability

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10
Q

Carbamazepine: Indications (3)

A

Epilepsy
Bipolar
Trigeminal neuralgia

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11
Q

Carbamazepine: Contraindications (3)

A

AV conduction abnormality
Acute porphyria
Pregnancy

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12
Q

Carbamazepine: Side Effects (3)

A

Ataxia
Hyponatraemia
Oedema

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13
Q

Carbamazepine: Interaction

A

P450 inducer

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14
Q

Sodium Valproate: Action

A

Weak inhibitor of Na channels

Increases concentration of y-aminobutyric acid => regulate excitability

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15
Q

Sodium Valproate: Indications (2)

A

Epilepsy

Bipolar

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16
Q

Sodium Valproate: Contraindication

A

Women wanting to conceive/in 1st trimester

17
Q

Sodium Valproate: Side Effects (4)

A

Tremor
Ataxia
Behaviour change
Hair loss => curly

18
Q

Sodium Valproate: Interaction

A

P450 inhibitor

19
Q

Lamotrigine: Action

A

Sodium channel blocker

20
Q

Lamotrigine: Indication

A

Focal and generalised seizures

21
Q

Lamotrigine: Contraindications (2)

A

Myoclonic seizures

Parkinson’s

22
Q

Lamotrigine: Side Effects (6)

A 
Dry mouth
Aggression
Agitation
Back pain
Arthralgia
Nystagmus
23
Q

Lamotrigine: Interactions (2)

A

Concentration decreased by oestrogen and rifampicin

Concentration increased by sodium valproate

24
Q

Levitiracetam: Action

A

Inhibit pre-synaptic calcium channels => impede impulse conduction

25
Q

Levitiracetam: Indications (3)

A

Focal, myoclonic and absence seizures

26
Q

Levitiracetam: Side Effects (5)

A 
Dyspepsia
Nasopharyngitis
Vertigo
Tremor
Headache
27
Q

Levitiracetam: Interaction

A

Increase plasma conc of methotrexate

Formulary (9 decks)

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