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academic weapon > MS1: Seronegative Spondyloarthropaties > Flashcards

MS1: Seronegative Spondyloarthropaties Flashcards

1
Q

what are spondyloarthropaties

A

group 2 inflammatory but non infectious - so negative sa RH factor

erosive din sha

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2
Q

what parts of the body do spondyloarthropaties usually affect

A

SI joint

sa IV disc

bony insertions ng mga tendon sa spine

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3
Q

classifications of spondyloarthropaties

A

inflammatory back pain

axial spondyloarthritis

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4
Q

mga disease under axial spondyloarthritis

A

ankylosing spondylitis

reiter’s

psoriatic arthritis

chronic inflammatory disease

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5
Q

general characteristics present in SS

A

negative RH
sacroilitis
axial involvement
peripheral arthrtis
enthesopathy
eye involvement
family clustering
LOM
HLA-B27

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6
Q

common symptoms SS

A

insidous onset of backpain at 30 yo for several months

pain more at rest - relieved by lakad

if may family history

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7
Q

discuss criteria of classification for axial spondyloarthritis

A

sacroilitis plus 2 other features

IBP
arhtritis peripheral
enthesitis
uveitis
dactylitis
psoriasis
crohns or UC
family history
HLA B27
elevated CRP

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8
Q

most common type of SS

A

ankylosing spondylitis

nag ffuse spine

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9
Q

discuss charactericts AS

A

chronic progressive inflammatory - SI pataas

undetermined cause

inflammation of insertion ng ligaments, tendons and capsules

may extraarticular involvement

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10
Q

primary joints affected AS

A

SI - hallmark

spine

large peripheral joints - hips and joints

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11
Q

hallmark joint of AS

A

SI

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12
Q

which popu is AS more common

A

males 35 yo.

genetic sa HLA-B27

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13
Q

classic presentation of AS

A

mid 20s sa male

middle or low back pain localized to pelvis, buttocks and hips

morning stiffness more than an hour - more than 3 mo.

paravertebral muscle spasm, aching stiffness

xray sacroilitis

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14
Q

PE of AS

A

dec mob = reduced lumbar flexion and lordosis

rarely tender and SI

spine becomes fused

+ schober’s test

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15
Q

lab findings of AS

A

+ HLA-B27
- RF and ANA
elevated ESR, serum IGA, bone alkanise phosphatase and CK

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16
Q

radiologic finding of ankylosing spondylitis

A

bamboo spine

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17
Q

complications of AS

A

fracture/SCI common sa cervical

osteoporosis

pseudoarthrosis sa thoracolumbar

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18
Q

discuss reactive arthritis

A

sterile infflamatory arthritis - reactive to infections away from joint

UTI ganun

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19
Q

discuss reiter’s syndrome

A

type of reactive arthritis

may triad - conjunctivitis, urethritis and arthritis

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20
Q

discuss DD of reactive from reiter

A

may triad yung reiter

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21
Q

discuss DD of reactive to septic arthritis

A

pag inaspirate no pus in joint sa reactive

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22
Q

how are reactive and reiters related

A

both positive for HLA-B27

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23
Q

features of reiters

A

triggered by infection - 1-4 wks after onset

fever, malaise, weight loss

assymetric affecting large joints

group 2 - sterile inflammatory

may extraarticular - eyes and mucocutaneous lesion

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24
Q

other name for reiters

A

oculo-urethro-synovial syndrome

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25
Q

hans reiter description of reiter’s

A

urethritis
conjunctivitis
arthritis following bloody diarrhea

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26
Q

what are the mucocutaneous lesion in reiters

A

oral ulcers
keratoderma blennorrhagica
circinata balatis
nail changes

4th criteria toh

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27
Q

common popu of reiters

A

3rd decade and less in children

men

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28
Q

discuss post venereal and dysenteric reiters syndrome

A

venereal - males
dysenteric - equal males and females

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29
Q

urogenital pathogens of reiters

A

chlamydia

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30
Q

enteric pathogens of reiters

A

shigella
salmonella
yersinia
campylobacter
vibrio

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31
Q

common joints affected of reiters

A

knees and ankles less sa SI

weight bearing joints of LE

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32
Q

discuss skin lesions reiters

A

resembles psoriasis

keratoderma blennorrhagica - soles, palms

circinata balatis - tite

onycholysis - nails

oral ulcers

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33
Q

other extraarticular manifestations in reiters

A

cardio-pulmo and nerve lesions

34
Q

determine if AS or reiters

no urethritis and conjunctivitis

A

AS

35
Q

determine if AS or reiters

urethritis and conjunctivitis is common

A

reiters

36
Q

determine if AS or reiters

SI and spine is involved and symmetric involvement

A

AS

37
Q

determine if AS or reiters

knee and ankle and assyemtric involvement

A

reiters

38
Q

what is psoriatic arhtritis

A

chroninc and recuurent tas erosive

GROUP 2 - associated w psoriasis

combines features of RA and spondyloarthropathies

39
Q

sex predilection of psoriatic

A

equal sex but women tend to develop symmertric and spinal involvement

40
Q

common age for psoriatic

A

20-30 yo

41
Q

discuss onset for psoriatic

A

acute or insidous preceded by skin disease

42
Q

risk factors fro psoriatic

A

unknown cause but HLA B27 marker is common

43
Q

common joints affected in psoriatic

A

DIP, spine and SI

precedes skin lesion after 1 yr

44
Q

pattern of arthritis in psoriatic

A

DIP - MCP and MTP later
assymetric oligo but symmetric poly
axial - ankylosing
arthritis mutilans - erosive

45
Q

SSx psoriasis

A

pain and stiffness in inflamed joint

morning stiffness more than 30 mins

pain on stressing joint, tenderness and effusion

aggravated by prolonged immob and reduced by rest

46
Q

if PSA or AS

less SI involvement

A

PSA

47
Q

if PSA or AS

back and neck pain LOM of lumbar and cervical

A

AS

48
Q

if PSA or AS

ankylosing

A

both

49
Q

if PSA or AS

20-30 yo

A

PSA

50
Q

if PSA or AS
40 up

A

AS

51
Q

if PSA or AS
SI changes in 10-30%

A

PSA

52
Q

if PSA or AS
agad na grade 4 sacroilitis

A

AS

53
Q

if PSA or AS

skin lesion

A

PSA

54
Q

dicuss dactylis in PSA

A

sausage digits - inflammation of tendon sheat in fingers

55
Q

nail lesion in PSAs

A

pitting
ridging
crackling
onycholysis

56
Q

other manifestations in psoriatic

A

uveitis
conjunctivitis
aortic valve insuff

57
Q

skin manifestations psoriatic

A

auspitz - pinpoint bleeding

koebners - new skin lesions on injured skin areas

58
Q

lab findings in psoriatic

A

+ HL4
- Rh

59
Q

radiologic findings in psoriatic

A

pencil cup deformity

60
Q

discuss inflammatory bowel disease

A

chronic inflammatory dieases in GIT

61
Q

causes of inflammatory bowel disease

A

genetic predispo
environment
autoimmune

62
Q

2 major types of inflammatory bowel disease

A

crohns
ulcerative colitis

63
Q

discuss occurence of inflammatory bowel disease

A

15-35 yo

UC - women
CD - men

64
Q

UC or CD

bloddy diaarhea

A

UC

65
Q

UC or CD
tender RLQ mass

A

CD

66
Q

UC or CD
acute flares

A

Uc

67
Q

UC or CD
indolent and chronic

A

CD

68
Q

UC or CD

rectal pain

A
69
Q

UC or CD

uveitis

A

CD

70
Q

UC or CD

erythma nodosum

A

CD

71
Q

UC or CD

aphtous ulcer

A

CD

72
Q

UC or CD

colitic arthirtis

A

CD

73
Q

UC or CD

ankylosing

A

UC

74
Q

UC or CD

cholangitis

A

UC

75
Q

UC or CD

amyloidosis leading to renal failure

A

CD

76
Q

UC or CD

gangrene

A

UC

77
Q

STD in reiter is commonly seen in

A

men

78
Q

GI involvment in reiter is commonly seen in

A

female

79
Q

what does post venereal reiters mean

A

disease is from sex - STD

80
Q

what does post dysneteric reiters mean

A

assoc w GI infection

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