MS

Question 1

Definition

Answer 1

CNS disorder

Progressive, degenerative neurological condition that compromises peoples ability to move

Autoimmune

Demyelinating disease
- destruction on myelin around neurons within the CNS

Question 2

Aetiology and pathophysiology

Answer 2

Autoimmune

Demyelination of neurons + oligodendrocytes in CNS

Nerve conduction becomes reduced or absent

Remyelination can occur; completely or partially restore function

Question 3

How is it diagnosed?

Answer 3

Clinical Assessment -> MRI

Question 4

Problems

Answer 4

All types possible: dependent on location of lesion

Sensory:
1. vision - diplopia, monocular blindness or HH

Heat sensitivity: heat slows down nerve conduction velocity or neurons
Fatigue

Question 5

males vs females

Answer 5

Females > males

Question 6

Predisposing factors

Answer 6

• genetic

- some environmental

Question 7

Sub-Classifications

Answer 7

Benign

Relapsing-Remitting (most common)

Secondary progressive (initially relapsing remitting -> then only relapses)

Primary progressive (constant decline)

Question 8

UMN or LMN

Answer 8

UMN

Question 9

Age of onset

Answer 9

young adulthood - 20-30 yrs