Motor Neuron Disease Flashcards
Supplementary to 3MB Neurology
9/10 MND diagnoses are familial and 1/10 are sporadic. True/false?
False - 9/10 are sporadic and 1/10 familial
At what age range does sporadic MND tend to occur?
50-75 years
ALS is less common in caucasian/non-caucasian populations?
Less common in non-caucasian
PLS is a very ____ type of MND. It presents with ______ signs and without muscle ______.
PLS is a very rare type of MND. It presents with UMN signs and without muscle wasting.
Progressive Muscular Atrophy is a very ____ type of MND. It presents with ____ signs and with muscle ____ and ____.
Progressive Muscular Atrophy is a very rare type of MND. It presents with LMN signs and with muscle wasting and fasciculations.
ALS is the ____ ______ type of MND. It presents with ____ and ____ signs.
ALS is the most common type of MND. It presents with UMN and LMN signs.
Describe presentation of ALS patient.
muscle wasting, fasciculations, increased tone, brisk reflexes, So UMN & LMN
Outline the presentation of progressive bulbar palsy MND?
wasted, fasciculated tongue, brisk reflex, hypotonic nasal speech, mixed UMN and LMN in mouth, normal peripheries
Which type of MND is fastest killer?
ALS
What is PLS and is it common/rare?
Primary lateral sclerosis - is rare
List 6 signs of UMN disease.
- spasticity
- stronger reflexes
- increased plantar response (Babinski sign)
- spastic gait
- slow movements
- exaggerated jaw-jerk
List 4 signs of LMN disease.
- muscle wasting
- fasciculations
- weakness
- absent/reduced reflexes
What is the difference between bulbar and pseudobulbar palsy?
Bulbar is an LMN lesion of CN IX, X and XII and pseudobulbar is UMN lesion of CN IX, X and XII
What is MND Catabolism?
sudden weight loss that occurs in 50% patients with MND
Bulbar onset occurs in approx. 2%/25%/70% patients?
Limb onset occurs in approx. 2%/25%/70% patients?
Thoracic onset occurs in approx. 2%/25%/70% patients?
Bulbar - 25%
Limb - 70%
Thoracic - 2%
