motor neuron degeneratin Flashcards
motor neuron disease
inherited or acquired
upper, lower or mixed
LMN diseases
poliomyelitis
amyotrophic lateral sclerosis
gullian barre
HIv AIDS
myasthenia gravis
immune response attacks NM junciton
can be treated
will affect strength and respirate mm
motor unit diseases
myasthenia gravis , duchenne
duchnen muscular
x linked recessive, survival >20 yrs
myotonic dystrophic
Guillain barre
rare rapid autoimmune disorder attacking myelin sheath of PNS
cause of Gillian barre
unknown but often preceded by infectious illness
first symptoms of Guillain barre
weakness / tingling extremities leading to paralysis of body
T/F guillian barre might need ventilator
yes
cure for Guillain barre
no but high dose immunoglobulin therapies can lessen severity
Gillian barre prognosis
varied
better outcome <40
many experience chronic pain /fatigue
might take weeks to years to recover
poliomyelitis
caused by viral infection
destruction of anterior horn (LMN)
leads to mm weakness
is poliomyelitis U or LMN
LMN
do ppl recover from polio
many recover
cure for polio?
no cure but prevented through vaccination
post polio syndrome
25-40% of individual who suffered an acute attack of poliomyelitis
symptoms appear 15-30yrs after original disease
slow progression
ALS cause
unknowns
ALS presentation
progressive, fatal disrupts signals to all mm
ALS u or L MN
both
UMN / LMN signs ALS
first seen in arms hands, legs and swallowing
equal bilateral mm weakness
progress
spasticity , brisk reflexes
is sensation bladder or ocular mm spared in ALS
yes