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Therapeutics Test 2 > more GN disease states > Flashcards

more GN disease states Flashcards

1
Q

what is also known as berger disease

A

IgA nephropathy

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2
Q

what type of GN often leads to thrombosis

A

membranous nphropathy

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3
Q

what is the only type of GN that chlorambucil is used in

A

membranous nephropathy

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4
Q

IgA has what type of structure

A

pentamer

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5
Q

what is usual presenting symptom with immunoglobin A nephropathy

A

infection and peeing blood

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6
Q

who is mostly effected by Berger disease

A

young males ( prevalent in Japan)

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7
Q

what is the pathophysiology of Berger disease

A

IgA deposits on kidney triggering immune response.

immune complex mediated disease

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8
Q

what percent of Iga nephropathy pt.s progress to ESRD in 10 years

A

10-20%

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9
Q

what is the most common symptom coupled with IgA nephropathy?

A

respiratory infections

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10
Q

what is uncommon at presentation of IgA nephropathy

A

renal dysfunction

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11
Q

what non-pharm treatment is common with IgA nephropathy

A

gluten free diets (gluten causes immune response)

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12
Q

what are common drugs used in IgA nephropathy tx?

A
  1. phenytoin - reduces circulating IgA
  2. Steroids - reduce proteinuria and ESRD progression
  3. fish oil - reduce prostaglandin and leukotriene production
  4. ACE and ARB’s for all pt’s
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13
Q

what is the only disease state that uses fish oil?

A

IgA nephropathy

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14
Q

gluten free diets is included with what type of GN?

A

Immunoglobulin A Nephropathy

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15
Q

what is the only type of GN treated with fish oil

A

Immunoglobulin A Nephropathy

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16
Q

lupus nephritis is a complication of what

A

system lupus erythematosus

17
Q

who is most effected by lupus nephritis

A

young African American women

18
Q

what is needed to confirm diagnosis of lupus nephritis?

A

biopsy

19
Q

is lupus nephrotic or nephritic

A

both, not just one or the other

20
Q

the pathophysiology of lupus nephritis predominately effects what?

A

B-cells (become hyperactive), producing more autoantibodies.

21
Q

lupus symptoms/ presentation has what?

A 
red cells (looks nephritic) in urine
ranges from hematuria and proteinuria
HTN
22
Q

what types of treatment are given for lupus nephritis

A

methylprednisolone followed by prednisone taper

combined with cyclophosphamide or mycophenolate

23
Q

what other treatment is given for lupus nephritis for resistant cases

A

rituximab

24
Q

what is the MOA of rituximab

A

inhibits CD20 on B-cells, taking them out of circulation
or
Depeletes immature B Cells

Therapeutics Test 2 (31 decks)

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