more GN disease states Flashcards
what is also known as berger disease
IgA nephropathy
what type of GN often leads to thrombosis
membranous nphropathy
what is the only type of GN that chlorambucil is used in
membranous nephropathy
IgA has what type of structure
pentamer
what is usual presenting symptom with immunoglobin A nephropathy
infection and peeing blood
who is mostly effected by Berger disease
young males ( prevalent in Japan)
what is the pathophysiology of Berger disease
IgA deposits on kidney triggering immune response.
immune complex mediated disease
what percent of Iga nephropathy pt.s progress to ESRD in 10 years
10-20%
what is the most common symptom coupled with IgA nephropathy?
respiratory infections
what is uncommon at presentation of IgA nephropathy
renal dysfunction
what non-pharm treatment is common with IgA nephropathy
gluten free diets (gluten causes immune response)
what are common drugs used in IgA nephropathy tx?
- phenytoin - reduces circulating IgA
- Steroids - reduce proteinuria and ESRD progression
- fish oil - reduce prostaglandin and leukotriene production
- ACE and ARB’s for all pt’s
what is the only disease state that uses fish oil?
IgA nephropathy
gluten free diets is included with what type of GN?
Immunoglobulin A Nephropathy
what is the only type of GN treated with fish oil
Immunoglobulin A Nephropathy
lupus nephritis is a complication of what
system lupus erythematosus
who is most effected by lupus nephritis
young African American women
what is needed to confirm diagnosis of lupus nephritis?
biopsy
is lupus nephrotic or nephritic
both, not just one or the other
the pathophysiology of lupus nephritis predominately effects what?
B-cells (become hyperactive), producing more autoantibodies.
lupus symptoms/ presentation has what?
red cells (looks nephritic) in urine ranges from hematuria and proteinuria HTN
what types of treatment are given for lupus nephritis
methylprednisolone followed by prednisone taper
combined with cyclophosphamide or mycophenolate
what other treatment is given for lupus nephritis for resistant cases
rituximab
what is the MOA of rituximab
inhibits CD20 on B-cells, taking them out of circulation
or
Depeletes immature B Cells
