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Therapeutics Test 2 > HTN5 > Flashcards

HTN5 Flashcards

1
Q

what are the trade names for nifedipine

A

Procardia and Adalat

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2
Q

what is the trade name for amlodipine?

A

Norvasc`

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3
Q

what is the trade name for felodipine

A

Plendil

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4
Q

what is the trade name for Nicardipine

A

Cardene

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5
Q

what is the trade name for isradipine

A

DynaCirc

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6
Q

What are the trade names fo Verapamil

A

Calan, Isoptin, and Verelan

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7
Q

what are the trade names for Diltiazem?

A

Cardizem and Dilacor

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8
Q

what abbreviations mean daily

A

CD and XR

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9
Q

what abbreviation means BID

A

SR

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10
Q

what are beta blockers effects on:

  1. CO
  2. renin release
  3. PVR
A

decreases all 3 (CO, renin release, and PVR with chronic use)

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11
Q

what are the adverse effects of beta blockers

A
  1. bradycardia
  2. second or third degree heart block
  3. Acute heart failure
  4. CNS effects
  5. sexual dysfunction
  6. discontinuation syndromes
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12
Q

how are discontinuation syndromes with BB’s avoided

A

taper gradually over 1-2 weeks

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13
Q

what are the adverse effects of BB’s on the CNS

A

fatigue
insomnia
bizarre dreams
depression

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14
Q

what causes fatigue with BB’s

A

compensation mechanisms of heart slows it down

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15
Q

what is the cardioselectivity of beta blockers

A

dose dependent B1 selectivity

-high doses give less selectivity for B1

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16
Q

what refers to both the beta blocking and partial beta stimulating effects of beta clockers in the resting state?

A

Intrinsic Sympathomimetic Activity (ISA)

17
Q

Beta blockers with high ISA do not treat what as well as other BBs?

18
Q

what is associated with high lipid solubility in BB

A

high lipid solubility increases CNS effects

19
Q

what are the combined, alpha and beta antagonists (classified as BBs)

A

labetalol

Carvedilol

20
Q

describe the selectivity of labetolol

A

nonselective B1 and B2 blocker

highly selective for a1 receptors

21
Q

describe the receptor selectivity for Carvedilol

A

nonselective for B1, B2, and a1

22
Q

what is the trade name of labetalol

23
Q

what is the trade name of Carvedilol

24
Q

what are the contraindications for BBs

A
  1. Heart Block
  2. Bradycardia
  3. Asthma/ COPD
  4. Noncompliance
  5. Diabetics
25
Q

why should BB not be used with diabetics

A

exacerbate hyperglycemia

26
Q

what should be monitored with pts on BBs

27
Q

what BBs have high lipid solubility

A

propranolol and carvedilol

28
Q

what BB has high ISA

A

Pindolol (VIsken)

29
Q

what is the 1st dose phenomenon with alpha blockers?

A

dizziness, faintness, palpitations and syncope

transient

30
Q

when should first dose of alpha blockers be given?

A

at bedtime

31
Q

what is the MOA of alpha blockers

A

blocks activation of post-synaptic a1 receptors

32
Q

what are the side effects of alpha blockers

A
  1. first dose effects
  2. orthostatic hypotension
  3. Na/ H2O retention

Therapeutics Test 2 (31 decks)

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