ckd3

Question 1

what should be started first: erythropoiesis-stimulating agents or iron

Answer 1

iron

Question 2

at what level should ESA be considered

Answer 2

hgb = 9-10

Question 3

at what level shold ESA be stopped

Answer 3

hgb exceeds 10

(or 11 on dialysis

Question 4

what is the dosing form, strength, and interval for epoetin alfa?
how bout in dialysis pts

Answer 4

50-100 units/ kg subq once weekly or every 2 weeks

dialysis: same, but IV and 1-2 times weekly

Question 5

what is the dosing form, strength, and interval for darboepoetin?
how bout in dialysis

Answer 5

.45 mcg/kg subq monthly

dialysis: .45 mcg/kg IV weekly or .75 mcg/kg IV every two weeks

Question 6

what is goal Hgb

Answer 6

11-12

Question 7

how often should Hgb be checked during ESA therapy

Answer 7

every 2 weeks until stable, then monthly

Question 8

doses of ESA should be changed in what time frame and increments?

Answer 8

once monthly by 25% max

Question 9

what level of Hgb change in two weeks calls for an increased dose

Answer 9

less than 1 g/dl change in hgb

Question 10

what level of Hgb change in two weeks calls for a decreased dose

Answer 10

more than 2 g/dl change in hgb

Question 11

what is BBW with ESAs

Answer 11

increased risk of CV events and mortality when target Hgb is > 11

Question 12

what is the most common adverse effect of ESAs

Answer 12

hypertension