GN treatment Flashcards
what are two specific therapy categories gor glomerulonephritis?
- immunosuppressants
2. plasmapheresis
what is plasmapheresis?
spinning out protein layer in blood, removing antibodies that cause glomerulonephritis
what makes more antibodies that can potentially cause GN when in circulation?
B cells
what are 4 immunosuppressives uses in GN treatment?
- corticosteroids
- cyclosporine
- mycophenolate/ azathioprine
- cyclophosphamide
why are corticosteroids an effective treatment
inhibit proinflammatory cytokines
what lymphocyte is responsible for proliferation of T-cells?
IL-2
what does cyclosporine inhibit in GN tx
IL-2 production
and other lymphokines
what does mycophenolate inhibit in GN tx
inhibits guanine synthesis
mycophenolates MOA is more specific for inhibiting what?
why is this?
T-cell specific (some B cells)
platelets, RBC’s… use salvage pathways, T-cells don’t use salvage pathways (de novo only)
what are guanine nucleotides imperative for?
RNA and DNA synthesis
what does azathioprine inhibit?
cellular purine synthesis
why is mycophenolate preferred to azathioprine?
azathioprine inhibits many cells in blood, causing many side effects
azathioprine is converted to what?
6-mercaptapurine
what immunosuppressant’s inhibit guanine synthesis
mycophenolate (guanine only) and azathioprine (all purines including guanine)
what is cyclophosphamides MOA?
inhibits DNA crosslinking, stopping cell division
