mood disorder pt2

Question 1

what is attention bias

Answer 1

difficulties disengaging attention from negative material
-depression

Question 2

what is attention bias more typical of

Answer 2

anxiety

Question 3

what is memory bias

Answer 3

preferential recall of negative compared to positive material

Question 4

what is perceptual bias

Answer 4

in depression: recognise negative faces more than positive faces

(extra info-depression enhances amygdala response to negative faces)

Question 5

what is amygdala function

Answer 5

bias towards detecting cues signalling potential threats, like expressions of fear- normal function

dysfunction - could be extreme bias….

processes facial expressions of emotion and reacts to both pleasant and aversive images, signalling the brain’s response to rewards or punishments

Question 6

Facial expression recognition modulation
by antidepressants in healthy volunteers- noradrenergic antidepressants vs serotonergic antidepressants
Acute single dose

Answer 6

Noradrenergic antidepressants (reboxetine, duloxetine):
better recognition of happy faces

Serotonergic antidepressants:
-mirtazapine: decreased recognition of fearful faces
-SSRI citalopram: mixed results

Question 7

Facial expression recognition modulation
by antidepressants in healthy volunteers- noradrenergic antidepressants and serotonergic antidepressants
7 days treatment

Answer 7

both reduce recognition of anger and fear
Neurofunctional: reduced amygdala response to fear