Monoengavirales - Rhabdoviridae Flashcards
Rhabdos meaning
Rhabdos = rod, stick -> plant rhabdoviruses
Morphology
-ssRNA genome, helical capsid (?), enveloped, big size
non-segmented
Complete virons
bullet shaped (B)
Incomplete virons
Truncated (T)
70% of virons are incomplete
Resistance
Weak
Replication
Baltimore V - viral transcriptase
Way of infections
cell-bound infections (=virions do not flow freely in the blood)
CPEs
weak - IF if necessary (can’t follow propagation (replication) even though they propagate fast)
fish vesiculovirus
thermosensitive
Is zoonoses possible?
yes
Antigenic properties
good antigens, cross-reactions within genera
Diagnosis
- IF, isolation + IF
- experimental infection + IF
- RT-PCR, serology: VN (combined with IF, bc. there’s no CPE’s), ELISA
Genus (20)
- Vesiculovirus
- Lyssavirus (->neves, not blood)
- Ephemerovirus
- Novirhabdovirus
Vesiculovirus:
Vesicular stomatitis virus
ungulates, human (America)
clinical signs: similar to FMD
-can be mistaken in Bo and Sus, but if found in Eq it’s defidently Vesiculovirus (because Eq is not succeptible to Foot & Mouth disease)
Vesiculovirus: Spring viraemia (NF!)
affects carp
-> hemorrae, ascites - only in cold water
Lyssavirus genus
meaning of lyssa
lyssa = rabies
Genotypes
16, but only need to know Rabies, the others are mosly found in bats
type of infection
neuroinvasive - lethal encephalitis: behavior changes
death when virus reaches the brain through the nervous sustem (time before death depends on where on the body infection starts - foot>face)
Prevention
sereal vaccination
urban rabies
dogs -> humans
Sylvatic rabies
fox, wolf, raccoon, bat
Accidental hosts
cat, horse, sheep, cattle
Ephemerovirus genus:
Bovine ephemeral fever
short fever - milk production decreases
-mosquito-transmitted (Africa, Asia and Australia)
Novirhabdovirus genus
- Viral haemorrhagic septicaemia
- Infectious haemopoetic necrosis
- Viral haemorrhagic septicaemia: Trous (Europe)
- Infectious haemopoetic necrosis: Salmon (Europe
