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virology > Nidoviridales > Flashcards

Nidoviridales Flashcards

1
Q

What does nidus mean?

A

nidus = nest (reffering to the nested set of subgenomic mRNA synthesis for the structural proteins)

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2
Q

Morphology

A

+ssRNA genome, helical capsid, enveloped & big

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3
Q

Resistance

A

good pH resistance (pH3-9), but heat labile

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4
Q

Replication strategy

A

Baltimore IV

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5
Q

Host specific?

A

yes, in vitro as well

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6
Q

CPEs

A

not characteristic (cell roundng & lysis)

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7
Q

Torovirus

A

zoonoses (gastroenteritis)

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8
Q

HA

A

varies (HEV)

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9
Q

Antigenic properties

A
  • relatively good antigens

- cross-reactions within genera - serogroups (IF, ELISA)

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10
Q

Diagnosis

  • direct
  • indirect
A

direct:
-isolation (difficult) + IF
-clinical signs, IF, IEM
indirect:
-ELISA, IF (cross-reactions), VN, HAI

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11
Q

Genus:

A

-Coronavirus
(alpha-, beta- and gammacoronavirus)
-Torovirus
(-Arteriviridae - arteritis)

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12
Q

Alphacoronavirus:

What is TGE, who and how does it affect?

A

TGE = Porchine transmissible gastroenteritis virus
affect piglets - severe enteritis, diarrhea
+respiratory form

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13
Q

Alphacoronavirus:

What is ED?

A

Ed = Porchine epidemic diarrhea virus

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14
Q

Alphacoronavirus:

What is FIP, who and how does it affect?

A

FIP = Feline infectious peritonitis virus
it is an immunocomplex disease which comes in a
-wet form: ascites, peritonitis
-dry form: nephriris, uremia

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15
Q

Other examlpes of alphacoronaviruses

A
  • CCV = canine coronavirus - enteritis, diarrhea

- human enteric coronavirus

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16
Q

Betacoronavirus:

What is BCV?

A

BCV = Bovine coronavirus - winter dysentery, calf diarrhea

17
Q

Betacoronavirus:

What is HEV?

A

HEV = Porchine hemagglutinating encephalomyelitis virus

18
Q

Betacoronavirus:
What is SARS?
-natural host?

A

SARS = Severe acute respiratory syndrome virus
human pneumonia-> decreased surfacant production
- atelectasia
Natural host: palm civet cat, bats

19
Q

Other examlpes of betacoronaviruses

A
  • MHV = Mouse hepetitis virus
  • Canine respiratory coronavirus - kennel cought syndrome
  • Human respiratory coronavirus
20
Q

Gammacoronavirus:

What is IB?

A

IB = Avian infectious bronchitis

  • > chichen: respiratory symptomes
  • > hens: egg deformaties
  • nephropathogen strains - nephrititis, gout
21
Q

What does Turkey bluecomb disease cause?

A

enteritis, diarrhea, exiccosis, cyanosis

22
Q

Other examlpes of gammacoronaviruses

A

Duck, Goose, Pigeon, Pheasant coronaviruses

23
Q

Torovirus:

What does torus mean?

A

Torus = base of a column

24
Q

Torovirus:

What is Berne virus?

A

Berne virus = foal gastroenteritis

25
Q

Torovirus:

What is Breda virus?

A

Breda virus = calf gastroenteritis

26
Q

Other examlpes of Toroviruses

A

Chichen, swine, human gastroenteritis

27
Q

Arteriviridae:

morphology

A

+ssRNA genome, icosahedral capsid, enveloped, medium size

28
Q

Arteriviridae:

resistance

A

weak (37°C, pH 6-8)

29
Q

Arteriviridae:

replication

A

Baltimore IV, subgenomic mRNA synthesis

30
Q

Arteriviridae:

CPEs

A

not characteristic

31
Q

Arteriviridae:

transmission

A

aerogen, sexual

32
Q

Arteriviridae:

antigenic properties

A

good antigens, no cross-reactions

33
Q

Arteriviridae:
diagnosis
-direct
-indirect

A
  • Direct: clinical signs, isolation (difficult), histopathology, IF, RT-PCR
  • Indirect: VN, ELISA
34
Q

Arteriviridae:

Genus

A

Arterivirus

35
Q

Arteriviridae:

what does EAV mean, and what does it cause?

A

EAV = equine arteritis virus

  • arteritis - edema, abortion, respiratory symptoms
  • stallions may become persistently infected - carry the virus in the genital tract, shed the virus by the semen
36
Q

Arteriviridae:

What does PRRS (SIRS) mean?

A

PRRS = prochine respiratory and reproductive syndrome
(SIRS = swine infertility and respiratory syndrome)
-> early abortion - infertility
-> respiratory symptoms - cyanosis (blue ear)

virology (12 decks)

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