Monoengavirales - Filoviridae

Question 1

meaning of filum

Answer 1

filum = thread

Question 2

morphology

Answer 2

-ssRNA genome, helical capsid, enveloped

Question 3

Resistance

Answer 3

Weak

Question 4

Replication

Answer 4

Baltomore V - viral transcriptase

Question 5

CPE

Answer 5

cytoplasmic inclusion bodies (easy to isolate)

Question 6

zoonoses?

Answer 6

yes! bats are reservoirs (not always symptoms in animals, but always in humans)

Question 7

antigenic properties

Answer 7

• good antigens in humans
• rapid course of lethal disease in human
• no cross reactions

Question 8

how does filoviridae affect humans

Answer 8

destroys antigen presenting cells (macrophages and dendritic cells) -> delayed immune response

Question 9

Diagnosis

Answer 9

• clinical symptoms - very specific

- isolation, EM, IF, RT-PCR

Question 10

Genera

Answer 10

• Ebolavirus
• Marburgvirus
• Cuevavirus

Question 11

Ebolavirus genus

why ebola?

Answer 11

Ebola = an African river, Congo

Question 12

Ebola viruses

-who, how?

Answer 12

Zaire-, Bundibugyo- Sudan-, Thai Forest ebolavirus

-human -> severe hemorrhage, encephalitis

Question 13

mortality

Answer 13

high (>90%)

Question 14

Reston virus

Answer 14

found in USA (Philipines). affect monkeys, not yet humans

-orphan?

Question 15

Marburgvirus

why marburg?

Answer 15

Margburg = first occurance in Margburg in Germany (introduced from Africa)

Question 16

spread

Answer 16

monkey -> human

-originating from bats - urine (airborne)

Question 17

symptoms of marburgvirus

Answer 17

fever, meningoencephalitis (less hemorrages, but more encephalitis than Ebola)

Question 18

Mortality

Answer 18

high, but less than Ebola bc. human-human transmission is rare, usually through primates

Question 19

Cuevavirus

meaning of cueva?

Answer 19

Cueva = cave

Question 20

Lloviu virus

Answer 20

affects bats in Span, don’t know effect on other species