Arenaviridae

Question 1

meaning of arena

Answer 1

arena = sand

Question 2

Genus

Answer 2

• Mammarenavirus

- Raptarenavirus

Question 3

Morphology

Answer 3

-ssRNA (ambisense) genome, segmented(2), no capsid(!), pleumorhic, enveloped, big size, ribosomes inside the viron has no function

Question 4

what does -ssRNA (ambisense) genome mean?

Answer 4

it can be read from both 3’ and 5’

Question 5

Resistance

Answer 5

weak

Question 6

Replication

Answer 6

Baltimore V - viral transcriptase

Question 7

zoonoses?

Answer 7

yes - ruminants -> humans

Question 8

Reservoir hosts

Answer 8

rodents (not pathogenic, only carriers)

Question 9

Antigenic properties

Answer 9

Good antigens, cross-reactions within genera

Question 10

Diagnosis

Answer 10

• isolatin, IF

- serology: VN, IIF

Question 11

Mammarenavirusgenus:

Old World arenaviruses

Answer 11

• Lymphocytic choriomeningitis virus (LCM): human meningitis - paresis, paralysis (pet hamsters -> children) in Europe, USA and Asia
• Lassa-, Mobala-, Moepia virus (Africa): hemorrhage, encephalitis

Question 12

Mammarenavirusgenus:

New World arenaviruses

Answer 12

Tacaribe-, Junun-, Machupo virus (South America): hemorrhage, encephalitis
-Rodents->humans

Question 13

Reptarenavirus genus

Snake arenaviruses

Answer 13

Inclusion body disease, cause neurological problems in Pythons and Boas