Monoengavirales - paramyxoviridae

Question 1

why mono?

Answer 1

non segmented -ssRNA viruses

Question 2

why paramyxo?

Answer 2

para = like, myxo = mucus

Question 3

Morphology

Answer 3

-ssRNA genome, helical capsid, enveloped, big size

Question 4

Resistance

Answer 4

weak (pH, heat, detergents)

Question 5

Replication

Answer 5

Baltimore V - viral transcriptase enzyme

Question 6

Proteins:

• HN
• F

Answer 6

HN = hemagglutinin ans neuraminidase activity
F = fusion proteins

Question 7

CPEs

Answer 7

cytoplasmic inclusion bodies, syncytia, hemadsorption

Question 8

Euryxen viruses

Answer 8

Respiro-, Rubula-, Avula-, Henipavirus

Question 9

More stenoxen viruses

Answer 9

Morbillivirus and Pneumovirinae

Question 10

Antigenic properties

Answer 10

Good antigens, coss-reactions within genera (Mobillivirus genus)

Question 11

Diagnosis

• direct
• indirect

Answer 11

• Direct: isolation, HA, IF

- Indirect: VN, HAI

Question 12

Genus

Answer 12

• Paramyxovirinae
• Respirovirus (respiratory disease)
• Mobillivirus
• Rubulavirus
• Avulavirus
• Henipavius
• Ferlavirus
• Pneumovirinae - Pneumovirus
• Metapneumovirus

Question 13

Paramyxovirinae:

examples

Answer 13

• Parainfluenza virus 1: human influenza-like disease

- Parainfluenza virus 3: cattle, sheep - shipping

Question 14

Respirovirus:

examples

Answer 14

fever, human influenza-like disease

-Sedai virus: rodents, rabbit - pneumonia, encephalitis

Question 15

Morbioolivirus:

why morbilli?

Answer 15

morbilli = measles

Question 16

Morbioolivirus:
Canine distemper virus (NF)
-who, how?

Answer 16

Affect dogs, bear, mink, lion, tiger, jaguar etc.

• Acute: fever, respiratory symptoms
• Subacute, chronic: encephalitis

Question 17

Morbioolivirus:

other examples

Answer 17

• Phocine distemper virus: seal - fever, pneumonia

- Cetacean morbillivirus: whale, dolphin - fever, pneumonia

Question 18

Morbioolivirus:

Rinderpest

Answer 18

affects rumonants -> fever, hemorrage, mucosal erosions

-under eradication in Africa

Question 19

Measles (morbilli)

Answer 19

human -> fever, rash

Question 20

Rubulavirus:

why rubula?

Answer 20

Rubula inflans = mumps

Question 21

Rubulavirus:

Parainfluenza virus 2

Answer 21

dog: kennel cough with CAV-2 and B. bronchiseptica
human: influenza-like disease (diff. from the canine)

Question 22

Rubulavirus:

Parainfluenza virus 4

Answer 22

human influenza-like disease

Question 23

Rubulavirus:

Mumps

Answer 23

human -> salivary gland swelling, orchitis, mastitis, encephalitis

Question 24

Avulavirus:

Newcastle disease

Answer 24

euryxen - birds, zoonosis

Question 25

Avulavirus:
Newcastle disease
-virulance variants:

Answer 25

lento-, mezo-, velogen strains

Question 26

Avulavirus:
Newcastle disease
-viscerotrop form
-neurtrop form

Answer 26

• viscerotrop form: hemorrage, high mortality

- neurotrop form: encephalitis

Question 27

Avulavirus:

Avian parainfluenza virus 2-9

Answer 27

Orphan

Question 28

Henipavirus:

Hendra virus

Answer 28

horse, human (Austalia) -> encephalitis

Question 29

Henipavirus:

Nipah virus

Answer 29

swine, human (Malaysia) -> encephalitis

Question 30

Ferlavrus:

Fer-de-Lance virus

Answer 30

snake pneumonia

Question 31

Pneumovirinae

pneumo meaning

Answer 31

pneuma = lung

Question 32

Pneumovirinae:

RS

Answer 32

RS = Bovine respiratory syncytial virus

-> severe pneumonia, intestinal emphysema

Question 33

Pneumovirinae:

other examples

Answer 33

• Murine pneumonia - mice

- Human respiratory syncytial virus

Question 34

Metapneumovirus

• TRT
• SHS

Answer 34

• TRT = turkey rhinotracheitis virus

- SHS = Swollen head syndrome - chicken