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2 Weeks > molecular baby > Flashcards

molecular baby Flashcards

1
Q

RNAS E function

A

processing the rRNA in prokayotes remove 5s
cleavage stage of the mrna in prokaryoe cleave the nik in the monophosphorylated mrna
polycisronic trna to monocistronic in trna cluster in prok
(processing of the trna, rrna and decay of the mrna in the prok)

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2
Q

ARE,

A

“AU-rich element,” 3’ untranslated region (UTR) of certain messenger RNA (mRNA)mRNA Stability Regulation: in eukarotes

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3
Q

uPf not ubf

A

uPf= bind to the EJC and have function in the quility control of the mrna ( non sense mediateed control )
ubf=up stream binding protein functioning in the rna pol 1

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4
Q

nonsense mediated decay

A

ejc bind to spliced + upf
2- sensing there is one more
upf+ post termination complex == trigger it

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5
Q

ski7

A

in no end decay the quility control of the mrna in the euk
bind to silimilr to rf3
release and degredade the mrna and protein
interacts with the exosome

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6
Q

quility control of the euk of mrna

A

1- non sensedecay(upf+ejc+post termination complex )
2-no go decay
3-non stop deacy (ski7+exosome +=)

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7
Q

Myeloid leukemia

A

Disease translocation fusedpr which is way active leads to cancer

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8
Q

dna methyl tramsferases

A

methylation catlysis the cyetein in the cpg sequences

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9
Q

central dogma lack….

A

regulation

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10
Q

some dnmts metylate dna during repllication t/f

A

true

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11
Q

DNMT1

A

main the tissue specific methylation patterin thurgh mitosis
maintenance methyltransferase

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12
Q

DNMT3A

A

de novo methylation

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13
Q

tet protein

A

demethylases

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14
Q

MBP

A

methyl cytosine binding protein

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15
Q

Histon deacetylation

A

compact the dna
cooporeate with the dn amethylation and methylation

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16
Q

DMR

A

differently methylated regions
related to genomic imprinting

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17
Q

2 imprinted genes and what each importent orginally

A

1gf2 = paternal
h19=maternal

18
Q

only paternal chromomse

A

dificient of the body development

19
Q

only maternal

A

extramaembryonic

20
Q

parthenogenetic embryo

A

1 parent unfertilized egg
not possible by the imprinted genes

21
Q

TET PROTEIN

A

esponsible for the demethylation of 5-methylcytosine (5mC) in DNA.

22
Q

2 WAVES OF THE DEMETHYLATION

A

1- ACQUISITION OF TOTIPOTENCY IN FERTILIZATION
2- SEX SPECIFIC IN GERM LINE FORMATION

23
Q

nucleosome

A

basic unit of the chromatin

24
Q

assembly nuclesome

A

teteramer h3 2 h4 2
2 dimer h2 a and h2 b

25
Q

chamge the property of th ehistone

A

tail

26
Q

linker vs central region

A
27
Q

k

A

lysine

28
Q

R

A

argenin

29
Q

H3K4ME3

A

HISTONE 3
LYSINE 4
3 METHYLATED

30
Q

BROMO

A

Regulatory proeitn that bind to bromodomain on the HAT

31
Q

HAT

A

HISTONE ACEYTL TRANSFERS
TRANSFER THE ACETYL TO HISTON TAIL

32
Q

CHROMO

A

REGULATORY FACTORS BIND TO METHYLATED

33
Q

kcooh

A

acertylation in lysin

34
Q

p300

A

cpb
a ttype of a co-activator and also HAT
affinity of the histon and the dna decrease nd increase the transciption
wrtier + hat

35
Q

pioneer factors

A

specific trasncrtiption factors that inititira the gene expression by opening the chromatin /displace nucleosome

36
Q

HMT VS MT

A

HISTON METHYL TRASNFERASE = METHYLATION OF THE HISTON LEADSING TO EITHER ACTIVATION OR INHIBITYION

MT= METHYL TRAMSFERASE JUST METHYLATION OF THE CYTOSINE IN THE CPG ISLAND AND ONLY INACTIVATION

37
Q

SUV39H

A

HMT
CHROMODOMAIN
METHYLATION H3K9

38
Q

H3K9ME

A

METHYLATION REPRESS AND ASSOCIATED TO DNA METHYLATIONN

39
Q

MBD

A

METHYL CPG BINDING DOMAIN

40
Q

IAP

A

TRANSPOSABLE EL;EMENT
IN THE AGOUTI LOCUS

41
Q
A

2 Weeks (10 decks)

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