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2 Weeks > MOLECULAR > Flashcards

MOLECULAR Flashcards

1
Q

IHF

A

bend dna- dnaA multimer help

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2
Q

DNA GYRASE

A

type of topisomerase
unwinding the dna (repication )
+ supercoil at downstream /block the transcription

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3
Q

ARS

A

sequence of the yeast, Autonomously Replicating Sequence, origin of replication

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4
Q

ORC)

A

protein complex involved in the initiation of DNA replication in eukaryotic cells,
bind to a, b1 of ARS bind oric

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5
Q

CMG COMPLEX

A

replication , initiation , euka
activated pre-rc
Orc+cdc6+cdt +mcm ….kinases(s cdk,ddk),+cdc45,GINS

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6
Q

deamination

A

induced / spon
G –XANTHINE
A— HHYPOXANTHINE

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7
Q

BASE ANALOGE

A

2BU(T) ; G
2AP/AMINO PURIN (A); C

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8
Q

ALKALTING AGENT
1-NAME?
2- EXAMPLES OF FUNCTION

A

1- MUSTARAT AGENT ,EMS /ETHYL METHANOSULAFATE
2- G+ ethyl = 6 ehtyl guanine : t
t+ethyl=4 ethyl thymine: g

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9
Q

oxidative reatction
1- name ?
2- exmaples

A

1- superoxide radical, hydrogen peroxide, hydroxyl radical
2-G = 8oxy7,8dihydrodeoxy G : A
TRANSVERSION
mispair

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10
Q

TRANSVERSION

A

OXIDATIVE REACTION

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11
Q

hydroxylamine
1- example

A

oh+ c=hydroxylamine c = rare tautomer: A
not reversable and repair !

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12
Q

intercalating agent
1- names ?
2- examples ?

A

1- proflavin , acridine orange , ethidium bromide , dioxine
intercalate distord 3d ,insertion and deletion fram shift
SEVER !!

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13
Q

PYRIMIDINE DIMER

A

MOSTLY 2 T BIND IN RESULT OF UV

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14
Q

INIOONIZING RADIATION

A

X RAY

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15
Q

DAM METHYLASE

A

METHYLATE A IN GATC
MISMATCH
RECOGNISITIO OLD VS NEW

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16
Q

MUTS,MUTL,MUTH

A

MISMATCH REPAR -BACTERIA

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17
Q

FORMULA OF CALCULATING THE GENOTYPE AND PHENOTYPE OF MONO,DI,TRI HYBRID CROSSES

A

2* N = PHENOTYPE

3*N = GENOTYPE

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18
Q

SUBMETA CENTRIC

A

LITTLE SHORT P-X CHROMOSME

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19
Q

ACROCENTRIC

A

VERY SHORT P -Y CHROMOMSE

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20
Q

SEX DETERMINATION IN DROSOPHILA

A

GENIC BLANCED SYSTEM

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21
Q

PURE BREEDING

A

ALL HOMOZYGOTE

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22
Q

HETEROHAMETIC

A

SEX DERERMIN DIFFERENT GAMET

23
Q

HEMIZYGOSITY

A

YX

24
Q

MRNP

A

MATURE RNA+ PR
SPLICING ACCURACY, EFFICIENCY TRANSLATION TRASNPORT TO CYTOPLASM

25
Q

EJC

A

EXON JUNCTION COMPLEX
TYPE OF MRNP
MRAK THE SPLICING SITES AFTER THE SPLICING

26
Q

GUID SEQUENCE

A

PART OF INTRONS IN TYPE 1 AUTOPLSING
HELP IN ALINGMENT I=OF EXONS
AND RECOGNATION INTRONS

27
Q

INTRON TYPE 2

A

6 STEM LOOP(RIBOZYME CHARECTERISTIC)+ ORF

28
Q

MGMT

A

Methyl guanine methyl transferases
Transfer the methyl de alkylation i
Functioning in the direct repair

29
Q

GgNER

A

Pathway of the ner
Global genome nucletide exicision repair
Uvr A, UvvrB without the Rna pol

30
Q

TC NER

A

Patheay of ner
Transcription coupled nucoeltide excision reapur
With rna pol

31
Q

Incision

A

Cut

32
Q

fto genes

A

apetite

33
Q

angiotensine

A

precouser proteins is formed by visceral adipose
constrict the blood vessels and the high pressure

34
Q

LOAD THE AMINO ACID ON THE CORROSPONDING TRNA

A

AMINOACYL TRNA SYNTHESISE

35
Q

ISOACEPTOR TRNA

A

TRNAS WOTG DIFFERNT ANTICODON BUT 1 AMINOACYL TRNA SYNTHEASE /AA

36
Q

INCISION IN NER OF EUK

A

XPB AND D

37
Q

Lynch syndrome

A

genetic defect in MMR
proteins, leading to
characteristic
microsatellite instability
in specific cancers

38
Q

TLS

A

TRANSLESION SYNTHEASE POLYMERASE

39
Q

SOS SIGNAL

A

HAPPEN AT TRANSLESION WHEN DNA POL STOP AT LESION

40
Q

RecA

A

strand exchange process during genetic recombination

41
Q

KU70-KU80

A

DETECT THE DSBREAKAGE
NHEJ REPAIR A TYPE OF DOUBLE STRAND BREKAAGE REAPIR

42
Q

HR

A

HOMOLOGOUS REPAIR- A TYPE OF DOUBLE STRANDE REPAIR

43
Q

DSBR

A

DOUBLE STRAND BREAK REPAIR- A TYPE OF THE HR WHICH IS A TTYPE OF DS BREAKAGE REPAIR
INVOVLE THE DOUBLE HOLLIDAY JUCNTION
CAN BE NON CROOS OVER OR CROSS OVER

44
Q

RAD51 is
homologous to….IN BACTERIA

A

l RecA

45
Q

SDSA

A

SYNTHESIS-DEPENDENT STRAND ANNEALING - A TYPE OF HR WHICH IS A TYPE OF DOUBLE STRAD REPAIR

46
Q

LYNCH SYNDROM

A

RELATED TO MUTATION IN COMONENTS IN MMR PATHWAY SO THEY ARER MORE LIKE TO SYFFER FROM THE CANCER

47
Q

MutL
homologs N EUK

A

MLH

48
Q

MutS
homologs

A

MSH

49
Q

RAD51 HOMOLOGOUS TO…

A

REC A IN BSCTERIA

50
Q

SPO11

A

e initiation of genetic recombination during meiosis

51
Q

SPO11

A

A meiotic proteine initiation of genetic recombination during meiosis

52
Q

dNTP

A

deoxyribonucleotide triphosphate

53
Q

POSTIVE MODELS OF THE NATURAL SELECTION

A

1- HARD SWEEP

2- SOFT SWEEP STANDING / DE NOVO

3- POLYGENIC polygenic adaptation model
4- ADAPTIVE INTROGRESSION

54
Q
A

2 Weeks (10 decks)

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