Module 9 (Exam 3) Diabetes Flashcards
Gestational Diabetes
A classification of diabetes with onset or first recognition during pregnancy
Polyhydramnios
Greater than normal amounts of amniotic fluid
Carbohydrate Metabolism
- Insulin
- Beta cells of pancreas
- Makes glucose available to body cells
- Diabetes
- Inadequate insulin and/or inability to use insulin for carbohydrate metabolism
Type I Diabetes
Insulin deficiency
Exists prior to pregnancy
Type II Diabetes
Insulin resistance
Incidence of gestational diabetes
Prevalence varies in direct proportion to prevalence of type II diabetes in a given segment of society
7% incidence
GDB Risk Factors
- BMI greater than 25-29 (overweight) or greater than 29 (obese)
- Chronic HTN
- Maternal age greater than 25
- Family history of diabetes
- History fetal macrosomia
- Unexplained fetal death in utero
- Multigestation
Early pregnancy diabetogenesis
- Insulin sensitivity
- Little alteration in maternal metabolic rate
- Potential for hypoglycemia
Late pregnancy diabetogenesis
- Insulin resistance
- Placental hormones block insulin usage
- Potential for hyperglycemia
- Placental hormones favor fetal growth
- Human placental lactogen and progesterone and estrogen
Why do insulin needs decline during the 1st trimester?
Insulin sensitivity
Why do insulin needs dramatically increase during the 2nd and 3rd trimesters?
- Insulin resistance peaks
- Placental blockers hamper insulin usage
Why do insulin needs dramatically decrease postpartum?
Placental delivery negates hPL
Screening for GDM
- Glucose Challenge Test
- Routine screening at 24-28 weeks gestation
- 50G oral glucose solution
- 1 hour postprandial blood draw
- Acceptable level is greater than 140mg/dl
- Finding of greater than or equal to 140mg/dl calls for a Oral Glucose Tolerance Test
Oral Glucose Tolerance Test
- Fasting blood glucose
- 100G oral glucose solution
- Postprandial blood draws every hour X 3
Diagnostic Criteria:
Fasting: greater than 95mg/dl
1 hour: greater than 180 mg/dl
2 hours: greater than 155mg/dl
3 hours: greater than 140mg/dl
What conditions must be met for a diagnosis of GDB?
Elevated fasting plasma glucose level
OR
Two or more elevated postprandial plasma glucose levels