Module 9

Question 1

The three major receptor types:

Answer 1

Mu, kappa, delta

Question 2

The receptor that produces central depression, analgesia, miosis, reduced gastrointestinal motility:

Answer 2

Mu

Question 3

An antagonist used in the treatment of opiate overdose:

Answer 3

Naloxone

Question 4

Peak of Opioid Abstinence Syndrome in humans:

Answer 4

48-72 hours

Question 5

When codeine is taken as a parent drug, approximately _______ is metabolized to morphine.

Answer 5

10%

Question 6

Duration of Opioid Abstinence Syndrome in humans:

Answer 6

7-10 days

Question 7

EDDP and EDMP are metabolites of:

Answer 7

Methadone

Question 8

Semisynthetic analgesic agonist derived from codeine that is used in cough syrups:

Answer 8

Hydrocodone

Question 9

Organic solvents are often used to extract opioids from aqueous mixtures in the pH range of:

Answer 9

8-10

Question 10

Used clinically since 1957, but recommended for removal from the U.S. drug market in 2010.

Answer 10

Propoxyphene

Question 11

What opioids are phenanthrenes?

Answer 11

Morphine, codeine, oxycodone, oxymorphone, hydrocodone, hydromorphone

Question 12

_______ is the major metabolic route for opioids that contain available hydroxyl (OH) groups.

Answer 12

Glucuronidation

Question 13

Successfully used for the treatment of respiratory depression after postsurgical opioid administration:

Answer 13

Nalbuphine

Question 14

This metabolite is more potent than morphine:

Answer 14

Morphine-6-glucuronide

Question 15

Has been used as a marker of poppy seed ingestion:

Answer 15

Thebaine

Question 16

Typical pKa values are:

Answer 16

7.6-8.9

Question 17

Used to manage intestinal upset and has been used to lessen withdrawal or produce euphoric effects:

Answer 17

Loperamide

Question 18

What opioids are phenylpiperidines?

Answer 18

Fentanyl, Alfentanl, Sufentanil, etc